The SYK tyrosine kinase: a crucial player in diverse biological functions.
The SYK tyrosine kinase: a crucial player in diverse biological functions.
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DOI：
10.1038/nri2765
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发表时间：
2010-06
期刊：
影响因子：
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通讯作者：
Tybulewicz VL
中科院分区：
文献类型：
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作者：
Mócsai A;Ruland J;Tybulewicz VL
已知脾酪氨酸激酶(SYK)传递获得性免疫受体信号。然而，最近的报道表明，SYK还调节其他出人意料的不同生物学功能，包括细胞黏附、先天免疫识别、破骨细胞成熟、血小板激活和血管发育。SYK被C型凝集素和整合素激活，并激活新的靶点，包括CARD9/CARMA1-Bcl10-MALT1途径和NLRP3炎症小体。对果蝇的研究表明，SYK介导的信号转导信号起源于进化的古代。此外，SYK在自身免疫性疾病和血液系统恶性肿瘤中起着至关重要的作用。这篇综述总结了我们目前对SYK功能的理解以及将这一知识转化为治疗目的的方法。
Spleen tyrosine kinase (SYK) has been known to relay adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates novel targets including the CARD9/CARMA1–BCL10–MALT1 pathway and the NLRP3 inflammasome. Drosophila studies indicate evolutionary ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of SYK functions and the translation of this knowledge for therapeutic purposes.