Failure of Cathodal Direct Current Stimulation to Improve Fine Motor Control in Musician's Dystonia
Failure of Cathodal Direct Current Stimulation to Improve Fine Motor Control in Musician's Dystonia
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DOI：
10.1002/mds.22938
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发表时间：
2010-02-15
影响因子：
8.6
通讯作者：
Altenmueller, Eckart
中科院分区：
文献类型：
--
作者：
Buttkus, Franziska;Weidenmueller, Matthias;Altenmueller, Eckart
音乐家肌张力障碍(MD)是一种特定于任务的运动障碍，在经过高度训练的动作中失去对运动的自主控制。中枢神经系统不同水平的缺陷抑制参与了其病理生理过程。阴极经颅直流电刺激(Ctdcs)可降低健康受试者运动皮质的兴奋性，并改善过度学习任务中的表现。这项研究的目的是调查ctdcs是否改善了MD患者的齿运动控制。10名专业吉他手(n=10)在训练前、训练后即刻、训练后60min进行训练。CTDCS2 mA，20min，作用于患手对侧的初级运动皮质。吉他练习被视频记录下来，症状由三名独立专家评估。未发现ctdcs对整个组的精细运动控制有有益影响。然而，一名吉他手的运动控制在刺激后有所改善。这名患者患有手臂肌张力障碍，而其他吉他手患有手部肌张力障碍。(C)2010年流动无序社会
Musician's dystonia (MD) is a task-specific movement disorder with a loss of voluntary motor control in highly trained movements. Defective inhibition on different levels of the central nervous system is involved in its pathophysiology. Cathodal transcranial direct current stimulation (ctDCS) diminishes excitability of the motor cortex and improves performance in overlearned tasks in healthy subjects. The aim of this study was to investigate whether ctDCS improves tine motor control in MD. Professional guitarists (n = 10) with MD played exercises before, directly after ctDCS, and 60 min after ctDCS. ctDCS (2 mA, 20 min) was applied on the primary motor cortex contralateral to the affected hand. Guitar exercises were video-documented and symptoms were evaluated by three independent experts. No beneficial effect of ctDCS on fine motor control was found for the entire group. However, motor control of one guitarist improved after stimulation. This patient suffered from arm dystonia, whereas the other guitarists suffered from hand dystonia. (C) 2010 Movement Disorder Society