Generation of a widespread Drosophila inversion by a transposable element
Generation of a widespread Drosophila inversion by a transposable element
复制标题
DOI：
10.1126/science.285.5426.415
复制
发表时间：
1999-07-16
期刊：
影响因子：
56.9
通讯作者：
Ruiz, A
中科院分区：
文献类型：
--
作者：
Cáceres, M;Ranz, JM;Ruiz, A
虽然多态倒置在果蝇中很常见，但这些染色体重排的起源尚不清楚。克隆并测序了buzzatii广域反转2j的断点。两个断点都包含与转座元素相对应的大插入。结果表明，插入后产生的两对目标位点重复序列在反位过程中发生了交换，反位是由两个方向相反的转座子拷贝之间的异位重组引起的。这显然是转座因子在果蝇中产生自然倒位的机制。
Although polymorphic inversions in Drosophila are very common, the origin of these chromosomal rearrangements is unclear. The breakpoints of the cosmopolitan inversion 2j of D. buzzatii were cloned and sequenced. Both breakpoints contain large insertions corresponding to a transposable element. It appears that the two pairs of target site duplications generated upon insertion were exchanged during the inversion event, and that the inversion arose by ectopic recombination between two copies of the transposon that were in opposite orientations. This is apparently the mechanism by which transposable elements generate natural inversions in Drosophila.