Modulation of impulse conduction along the axonal tree.
Modulation of impulse conduction along the axonal tree.
复制标题
沿轴突树的脉冲传导的调制。
DOI：
10.1146/annurev.bb.09.060180.001043
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
S. Waxman
中科院分区：
文献类型：
--
作者：
H. Swadlow;J. Kocsis;S. Waxman
As early as 1935, the experiments of Barr0n & Matthews (9) suggested that axons might not always conduct impulses faithfully but might, in fact, function in some systems as variable filters modulating the spatial and temporal relations between impulses. Subsequent advances in our understanding of axonal membrane mechanisms underlying the initiation and conduction of the action potential, along with advances in our understanding of the mechanisms of synaptic transmission and integration led to a relative neglect of the role of the axon in models of neural integration. Thus, the classical view of impulse conduction along the axon has been that of a transmission line, in which impulses initiated near the soma are faithfully distributed along the axonal arbors and reproduced at the axon terminals, and in which the temporal relations between impulses are maintained throughout the axonal tree. It is clear from cable theory, however, that geometrical constraints play a role in defining the characteristics of impulse conduction through a region of axon (see below). Thus, morphological inhomogeneities such as branchpoints and dilations may result in regions of low safety factor (ie regions where impulse conduction is likely to fail). In recent years has become clear that in some systems such regions of morphological
