CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma
CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma
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DOI：
10.1007/s00535-010-0235-3
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发表时间：
2010-08-01
影响因子：
6.3
通讯作者：
Ikemoto, Tetsuya
中科院分区：
文献类型：
--
作者：
Shimada, Mitsuo;Sugimoto, Koji;Ikemoto, Tetsuya
CD133是最重要的癌症起始（干）细胞标志物之一，并被证实在结肠癌等实体癌中表达。然而，尚未有人研究CD133在肝内胆管癌(IHCC)中的作用。本研究的目的是阐明CD133表达在IHCC中的临床作用。本研究纳入了29例在我机构接受肝切除术的IHCC患者。使用抗CD133抗体检查CD133的表达。癌细胞胞质染色，CD133阳性细胞分布于整个肿瘤。将患者分为两组：CD133阳性组（n = 14）和CD133阴性组（n = 15），其中未观察到CD133染色。比较两组之间缺氧诱导因子1α表达等临床病理因素。采用Cox比例风险模型对预后因素进行多因素分析。CD133阳性组5年生存率(8.0%)低于CD133阴性组(57.0%)。 CD133阳性组肝内转移发生率及缺氧诱导因子1α阳性表达率均高于CD133阴性组。多因素分析显示CD133表达是IHCC的独立预后指标。CD133表达往往与肝内转移发生率较高、缺氧诱导因子1α阳性表达有关；此外，它与较差的预后独立相关。因此，CD133的表达是IHCC潜在的预后指标。
CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer. However, no one has investigated the role of CD133 in intrahepatic cholangiocarcinoma (IHCC). The aim of this study was to clarify the clinical role of CD133 expression in IHCC.Twenty-nine patients with IHCC who underwent hepatic resection at our institution were enrolled in this study. Expression of CD133 was examined using anti-CD133 antibody. Staining was observed in the cytoplasm of cancer cells and CD133-positive cells distributed in the whole tumor. The patients were divided into two groups: the CD133-positive group (n = 14) and CD133-negative group (n = 15), in which no staining of CD133 was observed. Clinicopathological factors including hypoxia-inducible factor-1 alpha expression were compared between the two groups. The prognostic factors were investigated by multivariate analysis using Cox's proportional hazard model.The 5-year survival rate in the CD133-positive group (8.0%) was worse than that in the CD133-negative group (57.0%). In the CD133-positive group, the incidence of intrahepatic metastasis and positive expression of hypoxia-inducible factor-1 alpha tended to be higher than that in the CD133 negative group. The multivariate analysis revealed CD133 expression was an independent prognostic indicator in IHCC.CD133 expression tended to be related to higher incidences of intrahepatic metastasis and positive expression of hypoxia-inducible factor-1 alpha; furthermore, it was independently related to worse prognosis. Therefore, the CD133 expression is a potential prognostic indicator in IHCC.