Concise handbook of familial cancer susceptibility syndromes - second edition.
Concise handbook of familial cancer susceptibility syndromes - second edition.
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DOI：
10.1093/jncimonographs/lgn001
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Greene, Mark H
中科院分区：
文献类型：
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作者：
Lindor, Noralane M;McMaster, Mary L;Greene, Mark H
自从我们首次尝试开发可识别的家族癌症综合征的临床可访问目录以来，已经过去了10多年（1）。我们当时的感觉是，我们正处于关于人类肿瘤遗传基础的信息雪崩的边缘，这些新的分子见解的临床后果威胁着医疗保健提供者和他们的病人。我们试图将目前可用的与最常见的基因决定的癌症易感性综合征相关的数据提炼成一种格式，使这种《双城之战》知识更容易被偶尔需要这些信息的忙碌临床医生所获得。似乎不可避免的是，随着癌症易感性生殖细胞突变检测的疾病数量增加，需要更好地了解如何解决这些具有挑战性的临床问题。
More than 10 years have passed since we first attempted to develop a clinically accessible catalog of recognizable family cancer syndromes (1). Our sense at that time was that we were on the brink of an avalanche of information regarding the inherited basis of human neoplasia and that the clinical consequences of these novel molecular insights threatened to overwhelm both health-care providers and their patients. We attempted to distill currently available data related to the most common genetically determined cancer susceptibility syndromes into a format that would make this arcane knowledge more readily accessible to busy clinicians who only occasionally needed this information. It seemed inevitable that, as the number of disorders for which germline mutation testing for cancer susceptibility increased, the need for a better understanding of how to approach these challenging clinical problems would follow.