EXPERIMENTAL-STUDY FOR CANCER-DIAGNOSIS WITH POSITRON-LABELED FLUORINATED GLUCOSE ANALOGS - (F-18)-2-FLUORO-2-DEOXY-D-MANNOSE - A NEW TRACER FOR CANCER-DETECTION
EXPERIMENTAL-STUDY FOR CANCER-DIAGNOSIS WITH POSITRON-LABELED FLUORINATED GLUCOSE ANALOGS - (F-18)-2-FLUORO-2-DEOXY-D-MANNOSE - A NEW TRACER FOR CANCER-DETECTION
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DOI：
10.1007/bf00253423
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
IDO, T
中科院分区：
文献类型：
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作者：
FUKUDA, H;MATSUZAWA, T;IDO, T
18 F-2-氟-2-脱氧-D-葡萄糖（18F-FDG）和18 F-2-氟-2-脱氧-D-甘露糖（18F-FDM）作为肿瘤诊断剂在大鼠移植性肿瘤和兔移植性肿瘤中进行了试验。大鼠组织分布研究显示，两种放射性药物的肿瘤摄取量均较高。18F-FDG和28 F-FDM在60 min时的肿瘤摄取分别为2.65± 0. 61% dose 18F-FDG/g和2.65± 0. 81% dose 18F-FDM/g，120 min时仍保持相对稳定。18F-FDG和28 F-FDM的血液清除非常迅速，60 min时肿瘤/血液比值分别为22.1和29.4。18F-FDM正电子发射断层扫描（PET）可清楚显示肿瘤主体、中心坏死和淋巴结转移。这些数据表明，18F-FDG合成的副产物18F-FDM与18F-FDG一样，也是一种优良的癌症诊断剂。这不仅是18F-FDM的一个新特点，而且是PET诊断癌症的一个经济的改进。
18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and18F-2-fluoro-2-deoxy-D-mannose (18F-FDM) were tested as tumor diagnostic agents in a transplantable rat tumor and rabbit tumors. Tissue distribution studies in rats showed high tumor uptakes of both radiopharmaceuticals. The tumor uptake reached 2.65±0.61% dose18F-FDG/g and 2.65±0.81% dose18F-FDM/g at 60 min and remained relatively constant until 120 min. Blood clearance of both18F-FDG and28F-FDM was very rapid and tumor-to-blood ratios reached 22.1 and 29.4 at 60 min, respectively. Tumor-to-tissue ratios of both radiopharmaceuticals were very high in most organs, especially in the liver, kidney, and pancreas.Positron emission tomography (PET) of rabbit tumor with18F-FDM clearly delineated the main tumor, central necrosis, and lymph node metastases. These data suggested that18F-FDM which is a by-product of18F-FDG synthesis, was also an excellent cancer diagnostic agent as well as18F-FDG. This is not only a new feature of18F-FDM, but also an economical improvement on cancer diagnosis by PET.