Clinical correlates and heritability of flow-mediated dilation in the community - The Framingham Heart Study
Clinical correlates and heritability of flow-mediated dilation in the community - The Framingham Heart Study
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DOI：
10.1161/01.cir.0000112565.60887.1e
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发表时间：
2004-02-10
期刊：
影响因子：
37.8
通讯作者：
Vita, JA
中科院分区：
文献类型：
--
作者：
Benjamin, EJ;Larson, MG;Vita, JA
背景选定样本的研究已将内皮功能受损与心血管疾病及其危险因素联系起来。社区内皮功能的临床相关性和遗传性尚未被描述。方法和结果：我们对2883名Framingham研究参与者（52.9%为女性，平均年龄61岁）进行了内皮功能测量，肱动脉血流介导的扩张（FMD），以百分比（FMD%）和实际扩张来表示。1096名参与者在确定口蹄疫之前进行了6分钟步行测试。女性平均口蹄疫率为3.3+/-3.0%，男性为2.4+/-2.4%。在逐步多变量线性回归模型中，FMD%与年龄、收缩压、体重指数（BMI）、降脂药物和吸烟呈负相关，而与女性性别、心率和既往步行试验呈正相关。估计口蹄疫遗传率为0.14 %。FMD的实际扩张结果是相似的，除了女性性别和BMI没有显著相关。结论：在我们的社区样本中，年龄、收缩压、BMI和吸烟与较低的FMD%相关，而先前的运动和心率增加与较高的FMD%相关。口蹄疫的估计遗传力一般。未来的研究将允许更完整地描述内皮功能的遗传和环境决定因素及其在社区中的预后价值。
Background-Studies in selected samples have linked impaired endothelial function with cardiovascular disease and its risk factors. The clinical correlates and heritability of endothelial function in the community have not been described.Methods and Results-We examined a measure of endothelial function, brachial artery flow-mediated dilation (FMD), expressed as both percent (FMD%) and actual dilation by ultrasound with the occlusion cuff below the elbow in 2883 Framingham Study participants (52.9% women; mean age, 61 years). A subset of 1096 participants performed a 6-minute walk test before FMD determination. Mean FMD% was 3.3+/-3.0% in women and 2.4+/-2.4% in men. In stepwise multivariable linear regression models, FMD% was inversely related to age, systolic blood pressure, body mass index (BMI), lipid-lowering medication, and smoking, whereas it was positively related to female gender, heart rate, and prior walk test. The estimated heritability of FMD% was 0.14. FMD actual dilation findings were similar, except that female sex and BMI were not significantly associated.Conclusions-Increasing age, systolic blood pressure, BMI, and smoking were associated with lower FMD% in our community-based sample, whereas prior exercise and increasing heart rate were associated with higher FMD%. The estimated heritability of FMD was modest. Future research will permit more complete characterization of the genetic and environmental determinants of endothelial function and its prognostic value in the community.