The lung may play a role in the pathogenesis of rheumatoid arthritis.
The lung may play a role in the pathogenesis of rheumatoid arthritis.
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DOI：
10.2217/ijr.14.23
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Deane KD
中科院分区：
文献类型：
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作者：
Demoruelle MK;Solomon JJ;Fischer A;Deane KD
多项研究已确定肺和类风湿性关节炎（RA）之间存在密切联系。这些研究确定了在临床可分类的RA受试者中肺部疾病（气道和实质疾病）的高患病率。已经表明，RA中的肺部疾病是由循环自身免疫或其他因素（如药物）靶向肺部引起的。然而，发现肺部疾病，特别是炎症性气道疾病，和肺部产生的自身免疫性可能存在于关节症状发作之前，表明肺部的免疫反应可能参与RA相关自身免疫性的最初发展。在此，我们详细回顾了这些问题，以及概述了一个潜在的研究议程，以了解肺参与RA的自然史及其与RA的整体发病机制的关系。
Multiple studies have identified strong associations between the lung and rheumatoid arthritis (RA). Such studies identify a high prevalence of lung disease, both airways and parenchymal disease, in subjects with clinically classifiable RA. It has been suggested that lung disease in RA results from targeting of the lung from circulating autoimmunity or other factors such as medications. However, findings that lung disease, specifically inflammatory airways disease, and lung generation of autoimmunity can be present before the onset of joint symptoms suggest that immune reactions in the lung may be involved in the initial development of RA-related autoimmunity. Herein we review these issues in detail, as well as outline a potential research agenda to understand the natural history of lung involvement in RA and its relation to the overall pathogenesis of RA.