Milnacipran Inhibits Itch-Related Responses in Mice Through the Enhancement of Noradrenergic Transmission in the Spinal Cord
Milnacipran Inhibits Itch-Related Responses in Mice Through the Enhancement of Noradrenergic Transmission in the Spinal Cord
复制标题
DOI：
10.1254/jphs.13122sc
复制
发表时间：
2013-10-01
影响因子：
3.5
通讯作者：
Kuraishi, Yasushi
中科院分区：
文献类型：
--
作者：
Andoh, Tsugunobu;Gotoh, Yoshikazu;Kuraishi, Yasushi
我们研究了米那普仑，一种米那普仑-去甲肾上腺素再摄取抑制剂，是否通过小鼠脊髓作用表现出抗癫痫作用。鞘内注射米那普仑（0.1 - 10 μ g/部位）可显著抑制马槟榔诱导的叮咬，这是一种瘙痒相关反应。然而，使用氟伏沙明（10 μ g/部位）（一种选择性5-羟色胺再摄取抑制剂）未观察到这种作用。此外，腹膜内注射米那普仑（10 mg/kg）可抑制阿托宁诱导的叮咬。当鞘内注射非选择性α-肾上腺素受体拮抗剂酚妥拉明（1.0 μ g/部位）时，它抑制米那普仑的上述反应。这些结果表明，米那普仑通过抑制脊髓中去甲肾上腺素的再摄取来抑制瘙痒。
We investigated whether milnacipran, a serotonin-noradrenaline reuptake inhibitor, exhibits an antipruritic effect through the spinal action in mice. Intrathecal injections of milnacipran (0.1 - 10 mu g/site) significantly suppressed serotonin-induced biting, which is an itch-related response. However, such an effect was not observed with fluvoxamine (10 mu g/site), which is a selective serotonin reuptake inhibitor. Furthermore, an intraperitoneal injection of milnacipran (10 mg/kg) inhibited serotonin-induced biting. When phentolamine (1.0 mu g/site), a non-selective alpha-adrenoceptor antagonist, was intrathecally injected, it inhibited the above response of milnacipran. These results suggest that milnacipran suppresses itching through the inhibition of noradrenaline reuptake in the spinal cord.