Association of PPARγ gene polymorphisms with osteoarthritis in a southeast Chinese population
Association of PPARγ gene polymorphisms with osteoarthritis in a southeast Chinese population
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DOI：
10.1007/s12041-014-0444-2
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发表时间：
2014-12-01
影响因子：
1.5
通讯作者：
Fu Qiwei
中科院分区：
文献类型：
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作者：
Ding Zheru;Fu Peiliang;Fu Qiwei
在发达国家，原发性骨关节炎(OA)是导致残疾的主要原因。目前还没有令人满意的阻止疾病进展的治疗方法。最近的研究表明，转录因子过氧化物酶体增殖物激活受体γ(PPARγ)的激活是治疗本病的一个有趣的靶点。PPAR-γ是一种重要的转录因子，对脂肪形成和脂肪细胞分化具有重要作用。PPAR-γ激动剂在体内和体外均能抑制炎症反应，减少软骨降解产物的生成，从而减少骨关节炎动物模型软骨损伤的发生和发展。然而，目前还没有研究评估PPAR-γ在中国人群外周关节骨性关节炎易感性中的作用。我们在中国东南部人群中进行了一项病例对照研究，以确定PPARγ基因(rs1801282、rs12629751、rs2292101、rs4135275和rs1175543)与骨性关节炎的相关性。对100例膝关节骨性关节炎患者和100例正常对照进行研究。在该人群中，OA组和对照组之间的基因型和等位基因频率在统计学上有显著差异。单核苷酸多态rs12629751变异等位基因T的风险最高(OR=0.341，95%可信区间0.173~0.673，P=0.002)，等位基因T(卡方检验：9.546，P=0.002)可作为膝骨性关节炎的危险因素。因此，PPARγ突变可能与中国人群中骨性关节炎的发生有关。在中国东南部人群中，PPAR Gamma基因rs12629751与膝骨性关节炎的易感性显著相关。
Primary osteoarthritis (OA) is a leading cause of disability in developed countries. Currently no satisfactory treatment to stop disease progression exists. Recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR gamma) is an interesting therapeutic target for this disease. PPAR gamma is a transcription factor important for adipogenesis and adipocyte differentiation. Agonists of PPAR gamma inhibit inflammation and reduce generation of cartilage degradation products both in vitro and in vivo, and reduce the development/progression of cartilage lesions in OA animal models. However, there are no studies to assess the role of PPAR gamma in OA susceptibility of human peripheral joints in a Chinese population. We conducted a case-control study in a southeast Chinese population to determine the association of PPAR gamma gene polymorphisms (rs1801282, rs12629751, rs2292101, rs4135275 and rs1175543) with OA. One-hundred knee OA cases and 100 controls were studied. Statistically significant differences were detected in genotype and allele frequencies between OA and control groups in this population. For knee OA, the highest risk was associated with the variant allele T of the single-nucleotide polymorphism rs12629751 (odds ratio (OR): 0.341, 95% confidence interval (CI):0.173-0.673, P = 0.002), and allele T of SNP rs12629751 (chi-square: 9.546, P = 0.002) could be considered as a risk factor of knee OA. Therefore, PPAR gamma mutation could be associated with the incidence of OA in a Chinese population. There is a significant association between the PPAR gamma polymorphism rs12629751 and susceptibility to knee OA in a southeast Chinese population.