Functional Significance of Nonspatial Information in Monkey Lateral Intraparietal Area
Functional Significance of Nonspatial Information in Monkey Lateral Intraparietal Area
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DOI：
10.1523/jneurosci.0243-09.2009
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发表时间：
2009-06-24
影响因子：
5.3
通讯作者：
Gottlieb, Jacqueline
中科院分区：
文献类型：
--
作者：
Balan, Puiu F.;Gottlieb, Jacqueline
虽然顶叶皮层传统上与空间知觉和运动规划有关，但最近的证据表明，外侧顶内区（LIP）的神经元携带空间和非空间信号。顶叶皮层中的非空间信息的功能意义尚不清楚。为了解决这个问题，我们测试了单侧可逆失活的LIP的三个行为任务，已知引起非空间反应的影响。每个任务包括一个空间组件（目标选择在hemifield对侧或同侧的失活）和一个非空间组件，即肢体运动规划，估计经过的时间，和奖励为基础的决策。虽然失活可靠的性能受损的所有任务，赤字是空间特定的（仅限于对侧的目标位置），并没有影响非空间方面的性能。这表明LIP中的调制非空间信号代表关于在其他地方执行的计算的反馈，而不是LIP在这些计算中的主要作用。
Although the parietal cortex is traditionally associated with spatial perception and motor planning, recent evidence shows that neurons in the lateral intraparietal area (LIP) carry both spatial and nonspatial signals. The functional significance of the nonspatial information in the parietal cortex is not understood. To address this question, we tested the effect of unilateral reversible inactivation of LIP on three behavioral tasks known to evoke nonspatial responses. Each task included a spatial component (target selection in the hemifield contralateral or ipsilateral to the inactivation) and a nonspatial component, namely limb motor planning, the estimation of elapsed time, and reward-based decisions. Although inactivation reliably impaired performance on all tasks, the deficits were spatially specific (restricted to contralateral target locations), and there were no effects on nonspatial aspects on performance. This suggests that modulatory nonspatial signals in LIP represent feedback about computations performed elsewhere rather than a primary role of LIP in these computations.