The role of segment polarity genes during Drosophila neurogenesis.
The role of segment polarity genes during Drosophila neurogenesis.
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DOI：
10.1101/gad.3.6.890
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发表时间：
1989-06
影响因子：
10.5
通讯作者：
N. Patel;B. Schafer;C. Goodman;R. Holmgren
中科院分区：
文献类型：
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作者：
N. Patel;B. Schafer;C. Goodman;R. Holmgren
果蝇的体节极性基因对于每个体节内表皮模式的正确形成是必需的。在此我们表明，某些体节极性基因对于果蝇胚胎发育中的中枢神经系统（CNS）中特定神经元特性的决定也是至关重要的。然而，对于一些突变体，其模式缺陷并不简单地与其表皮表型平行。在融合基因（fused）、犰狳基因（armadillo）和肘脉中断显性基因（cubitus interruptus Dominant）突变体中，中枢神经系统的大部分看起来相对正常。在刺猬基因（hedgehog）突变体中，中枢神经系统高度紊乱，但这种紊乱可能发生在神经发生的初始事件之后。斑驳基因（patched）突变体中的特定细胞缺陷表明，该基因指定了位于表皮模式缺陷区域下方的一部分成神经细胞和神经后代。醋栗基因（gooseberry）突变体在表皮修饰区域下方和外侧都显示出一系列复杂的神经元特性改变。在细胞基因（Cell）突变体中，沿中线的一组细胞的神经元特性似乎发生了改变。无翅基因（wingless）突变体的表型是最受限的，可能是由于同胞神经元之间的通讯不当所致。因此，除了在表皮模式形成中的功能外，至少有四种体节极性基因（醋栗基因、斑驳基因、细胞基因和无翅基因）似乎在神经发生过程中对细胞命运的控制具有特定作用。
Segment polarity genes in Drosophila are required for the proper formation of epidermal pattern within each segment. Here we show that certain segment polarity genes are also critical for the determination of specific neuronal identities in the developing central nervous system (CNS) of the Drosophila embryo. For several mutants, however, the pattern defects do not simply parallel their cuticular phenotypes. In fused, armadillo, and cubitus interruptus Dominant mutants, much of the CNS appears relatively normal. In hedgehog mutants, the CNS is highly disorganized, but this disruption may occur secondary to the initial events of neurogenesis. The specific cellular defects in patched mutants suggests that this gene specifies a subset of neuroblasts and neural progeny underlying the region of epidermal pattern defect. gooseberry mutants display a complex series of alterations in neuronal identity both underlying and outside of the region of epidermal modification. Neuronal identities of a set of cells along the midline appear to be changed in Cell mutants. The phenotype of wingless mutants is the most restricted and may be due to improper communication between sibling neurons. Thus, in addition to their functions in epidermal pattern formation, at least four of the segment polarity genes (gooseberry, patched, Cell, and wingless) appear to have specific roles in the control of cell fates during neurogenesis.