Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity
Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity
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DOI：
10.1111/adb.12557
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发表时间：
2018-09
影响因子：
3.4
通讯作者：
Reza Arezoomandan;Esmail Riahi;A. Haghparast
中科院分区：
文献类型：
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作者：
Reza Arezoomandan;Esmail Riahi;A. Haghparast
累积的证据表明，米诺环素（一种神经胶细胞调节剂）能够在这里改变多种吗啡的作用，我们研究了米诺环素对伏伏核（NAC）神经元的电活动的影响，使用单个单位记录在尿素 - 尿素上的大鼠中，我们会在其他过程中进行纽约的效果。行为。在获取吗啡诱导的条件偏好（5 mg/kg，S.C。，3天）和无药物延长时，在吗啡治疗的动物中进行电生理记录。盐水。在记录中持续40分钟，将MG/kg持续了40分钟。一天，记录了NAC神经元10分钟，施用吗啡的启动剂量，我们的结果持续45分钟。
Accumulating evidence indicated that minocycline, a glial cell modulator, is able to modify a variety of morphine effects. Here, we investigated minocycline effects on electrical activity of nucleus accumbens (NAc) neurons using single unit recording in urethane‐anesthetized rats. In addition, we investigated whether minocycline can modify the effects of morphine on NAc neural activity during reinstatement of morphine‐seeking behavior. Minocycline increased the NAc firing activity in intact animals. Electrophysiological recording in morphine‐treated animals was performed, following the acquisition of morphine‐induced conditioned place preference (5 mg/kg, s.c., 3 days) and a drug‐free extinction period. In acutely minocycline‐ treated animals, the neurons were recorded for 40 minutes following a single injection of either minocycline (50 μg/5 μl, i.c.v.) or saline. Then a priming dose of morphine (1 mg/kg, s.c.) was injected while the recording was continued for an additional 40 minutes. Minocycline significantly increased the firing rates of neurons and significantly modified morphine inhibitory effects on NAc neurons. In subchronically minocycline‐treated groups, the rats were given daily injections of minocycline (50 μg/5 μl, i.c.v) during the extinction period. Then, on the reinstatement day, NAc neurons were recorded for 10 minutes, the priming dose of morphine was administered and the recording was continued for 45 minutes. Our results showed the failure of minocycline to significantly modify the inhibitory effects of morphine. In conclusion, our findings indicated that minocycline modifies morphine‐induced decreases in the firing rates of NAc neurons in the reinstatement phase.