Enantioselective Pd-Catalyzed Hydrogenation of Fluorinated Imines: Facile Access to Chiral Fluorinated Amines
Enantioselective Pd-Catalyzed Hydrogenation of Fluorinated Imines: Facile Access to Chiral Fluorinated Amines
复制标题
氟化亚胺的对映选择性钯催化氢化：轻松获得手性氟化胺
DOI：
10.1021/ol1020256
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发表时间：
2010-11-05
期刊：
影响因子：
5.2
通讯作者：
Zhou, Yong-Gui
中科院分区：
文献类型：
--
作者：
Chen, Mu-Wang;Duan, Ying;Zhou, Yong-Gui
以Pd(OCOCF3)(2)/(R)-Cl-MeO-BIPHEP为催化剂，研究了简单氟亚胺的对映选择性加氢反应，得到了94%的ee。该方法为制备对映体富集型氟胺提供了一条有效的途径。
An enantioselective hydrogenation of simple fluorinated imines has been developed using Pd(OCOCF3)(2)/(R)-Cl-MeO-BIPHEP as a catalyst, and up to 94% ee was achieved. This method provides an efficient route to enantioenriched fluorinated amines.