Lead-oriented synthesis of epigenetic relevant scaffolds.
Lead-oriented synthesis of epigenetic relevant scaffolds.
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表观遗传相关支架的先导合成。
DOI：
10.1039/d3cc04317g
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Burslem,GeorgeM
中科院分区：
文献类型：
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作者：
Maujean,Timothé;Kannaboina,Prakash;Green,AdamI;Burslem,GeorgeM
由此发展了一种简单合理的利用连续评价函数对分子类铅性进行排序的方法。该策略被证明与已知方法相比具有竞争力，并最终有助于推动针对HDAC 6、BRD 4和EZH2的表观遗传应用的感兴趣候选物的合成努力。
A simple and rational method to rank lead-likeness of molecules using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped in driving synthetic efforts towards candidates of interest for epigenetic applications against HDAC6, BRD4 and EZH2.