Disturbed solid-phase gastric emptying in functional dyspepsia - A meta-analysis
Disturbed solid-phase gastric emptying in functional dyspepsia - A meta-analysis
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DOI：
10.1023/a:1018803129779
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发表时间：
1998-09-01
影响因子：
3.1
通讯作者：
Hoes, AW
中科院分区：
文献类型：
--
作者：
Quartero, AO;De Wit, NJ;Hoes, AW
功能性消化不良是一种常见的疾病，具有多种病理生理背景，但运动障碍在功能性消化不良中的作用尚不清楚。我们的目的是量化胃排空障碍与功能性消化不良之间的关系，采用荟萃分析方法。通过Medline和Embase从1983年到1996年的结构化文献检索，我们选择了所有在功能性消化不良患者和对照组中测量固体相胃排空的研究。共纳入17项研究，涉及868名消化不良患者和397名对照。功能性消化不良患者胃排空速度比对照组慢1.46（1.23-1.69）倍；排空异常缓慢的患者比例为37%（34-40%，简单数字池）或39%（29-49%，加权池）。我们得出的结论是，功能性消化不良患者的胃排空固体比健康对照慢1.5倍，并且在近40%的功能性消化不良患者中存在明显的排空延迟。
Functional dyspepsia is a common disorder with a diverse pathophysiological background, but the role of motility disorders in functional dyspepsia remains unclear. We aimed to quantify the relationship between disturbed gastric emptying and functional dyspepsia, using a meta-analytic approach. Through a structured literature search of Medline and Embase from 1983 to 1996, we selected all studies in which scintigraphic solid-phase gastric emptying was measured in both functional dyspeptic patients and controls. Seventeen studies involving 868 dyspeptic patients and 397 controls were pooled. Gastric emptying in patients with functional dyspepsia was 1.46 (1.23-1.69) times slower than controls; the proportion of patients with abnormally slow emptying was either 37% (34-40%, simple numeric pooling) or 39% (29-49%, weighted pooling). We conclude that gastric emptying of solids in patients with functional dyspepsia is 1.5 times slower than in healthy controls and that a significant delay of emptying is present in almost 40% of patients with functional dyspepsia.