POST-RADIATION RETINOPATHY - A FLUORESCENCE FUNDUS ANGIOGRAPHIC STUDY
POST-RADIATION RETINOPATHY - A FLUORESCENCE FUNDUS ANGIOGRAPHIC STUDY
复制标题
DOI：
10.1136/bjo.54.11.705
复制
发表时间：
1970-01-01
影响因子：
4.1
通讯作者：
HAYREH, SS
中科院分区：
文献类型：
--
作者：
HAYREH, SS
由于局部眼部病变（如视网膜母细胞瘤或脉络膜恶性黑色素瘤）或邻近区域眼外病变（如胃窦癌和鼻癌、面部啮齿动物溃疡、眼睑鳞状细胞癌等）的放射治疗而导致的眼后段照射。已知在实际照射后数月或数年产生延迟的视网膜血管变化，并可能引起视力障碍。Stallard（1933，1936）首先报道了一例视网膜母细胞瘤患者经氡子植入治疗后的这些变化。他在放射治疗后20个月发现了一种环状视网膜病变，伴有视网膜出血和渗出物、视盘水肿和中央视网膜血管鞘化，最终导致视神经萎缩。放射后视网膜血管病变已被许多作者报道，包括Foster摩尔（I935），Pillat（I935），Renard和Duriez（I949），Martin和Reese（I949），03 The Dog's Dog（1952）（1950年，1958年），Stallard（95 96 i，1966），Perrers-Taylor，Brinkley，and Reynolds（1965），霍华德（1966），Chee（1968），Gass（1968），MacFaul and贝德福德（1970），and贝德福德，Bedotto，和MacFaul（1970）。荧光眼底血管造影术在各种类型的视网膜病变中的应用，为我们提供了迄今为止未知的信息。以前仅在两个病例中报告了放射后视网膜病变的荧光眼底血管造影结果（Gass，I 968和Chee，I 968，这两个作者报告了相同的病例）。最近，在伦敦Moorfields眼科医院应用钴-6 o治疗的三个脉络膜恶性黑色素瘤病例中注意到放射后视网膜病变（贝德福德等人，I 970）。这三个案例都进行了调查，荧光眼底血管造影。本研究揭示了一些有趣的视网膜血管改变，本文对此作了详细报道。基于这些发现描述了辐射后视网膜病变的模式，因为文献中没有关于该主题的详细描述。
Irradiation of the posterior segment of the eye resulting from radiotherapy either of local ocular lesions (eg retinoblastoma or malignant melanoma of the choroid) or ofextraocular lesions of the adjacent regions (eg carcinoma of the antrum and nose, rodent ulcer of the face, squamous cell carcinoma of eyelids, etc.) has been known to produce delayed retinal vascular changes which develop many months or years after the actual irradiation, and may cause disturbances of vision. Stallard (I933, 1936) first reported these changes in a case of retinoblastoma treated by implantation of radon seeds. He found a circinate type of retinopathy with retinal haemorrhages and exudates, oedema of the optic disc, and sheathing of the central retinal vessels 20 months afterirradiation, which ultimately caused optic atrophy. Post-radiation retinal vascular lesions have since been reported by many authors, including Foster Moore (I935), Pillat (I935), Renard and Duriez (I949), Martin and Reese (1942, 1945), Fry (1952), Cogan (I950, 1958), Stallard (95 96i, I966), Perrers-Taylor, Brinkley, and Reynolds (i965), Howard (I966), Chee (I968), Gass (I968), MacFaul and Bedford (1970), and Bedford, Bedotto, and MacFaul (1970). The use of fluorescence fundus angiography in various types of retinopathy in the recent past has given us hitherto unknown information on the subject. A brief account of fluorescence fundus angiographic findings in post-radiation retinopathy has previously been reported in only two cases (Gass, I 968, and Chee, I 968 the same cases being reported by the two authors).Recently, post-radiation retinopathly was noticed in three cases of malignant melanoma of the choroid treated by Cobalt-6o application at Moorfields Eye Hospital, London (Bedford and others, I970). These three cases have been investigated by fluorescence fundus angiography. TIhis study has revealed some interesting retinal vascular changes which are reported in detail in this paper. A pattern of post-radiation retinopathy based on these findings is described, as no such detailed account on the subject is available in the literature.