The Role of Central Amygdala Dopamine in Disengagement Behavior
The Role of Central Amygdala Dopamine in Disengagement Behavior
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DOI：
10.1037/a0031043
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发表时间：
2013-04-01
影响因子：
1.9
通讯作者：
Lee, Hongjoo J.
中科院分区：
文献类型：
--
作者：
Smith, Elizabeth S.;Geissler, Sydney A.;Lee, Hongjoo J.
动物单侧黑质纹状体多巴胺耗竭可引起对侧感觉运动障碍，类似帕金森病（PD）相关症状。单侧黑质纹状体多巴胺耗竭也会导致对侧脱离行为的缺陷（例如，例如，在一个实施例中，停止正在进行的活动以适应/注意新刺激的能力）。这种脱离缺陷已被证明对挽救其他运动和躯体感觉缺陷的治疗有抵抗力。因此，脱离行为可能涉及独特的感觉运动信息整合潜在的重要注意力分配，并可能强烈依赖于一种机制，包括小脑纹状体电路。杏仁核中央核（CeA）及其与黑质多巴胺系统的联系已被报道调节认知过程，这在很大程度上依赖于注意力分配。CeA多巴胺功能可能对脱离行为也很重要。在实验1中，大鼠接受微量输注6-羟基多巴胺单方面诱导多巴胺终端损失的CeA，并进行了测试的脱离行为，除了几个感觉运动功能。这些大鼠表现出对侧脱离行为的缺陷和从爪子上去除粘合剂点的不对称性，但在圆柱体或安非他明旋转中的前肢使用中没有。在实验2中，大鼠接受D1或D2拮抗剂到CeA单方面之前的行为测试。D1拮抗剂破坏脱离行为，而不影响其他感觉运动测试检查。D2拮抗剂对测试的任何行为都没有影响。我们的研究结果表明，CeA多巴胺功能参与调制的脱离行为。
Unilateral nigrostriatal dopamine depletion in animals induces contralateral sensorimotor deficits that are like symptoms associated with Parkinson's disease (PD). Unilateral nigrostriatal dopamine depletion also causes a contralateral deficit in disengagement behavior (e. g., ability to stop an ongoing activity to orient/attend to a new stimulus). This disengagement deficit has been shown to be resistant to treatments that rescued other motor and somatosensory deficits. Thus, disengagement behavior may involve unique sensorimotor information integration potentially important for attentional allocation and may rely strongly on a mechanism that includes extranigrostriatal circuitry. The central nucleus of the amygdala (CeA) and its connections with the nigral dopamine system have been reported to modulate cognitive processes dependent substantially on attentional allocation. CeA dopamine function might be also important for disengagement behavior. In Experiment 1, rats received microinfusions of 6-hydroxydopamine unilaterally to induce dopamine terminal loss in the CeA and were tested for disengagement behavior in addition to several sensorimotor functions. These rats showed deficits in contralateral disengagement behavior and an asymmetry in adhesive dot removal from the paws, but not in forelimb use in a cylinder or amphetamine rotation. In Experiment 2, rats received D1 or D2 antagonists into the CeA unilaterally prior to behavioral tests. The D1 antagonist disrupted disengagement behavior without affecting the other sensorimotor tests examined. The D2 antagonist had no effects on any of the behaviors tested. Our results suggest that CeA dopamine function is involved in modulation of disengagement behavior.