Possible role of anti-idiotypic antibodies in the induction of tumor immunity.
Possible role of anti-idiotypic antibodies in the induction of tumor immunity.
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DOI：
10.1172/jci113195
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发表时间：
1987-11
期刊：
影响因子：
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通讯作者：
R. Kennedy;E. Zhou;R. Lanford;T. Chanh;C. Bona
中科院分区：
文献类型：
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作者：
R. Kennedy;E. Zhou;R. Lanford;T. Chanh;C. Bona
独特型（Id）或独特型决定簇是抗体的抗原部分，包括分子的可变区（V）。在V区内是抗原特异性结合抗体的位点。Oudin和Michel（1）和Kunkel及其同事（2）的早期研究表明，Id对于一小组抗体分子是唯一的。然而，Ids也可以被对给定抗原具有特异性的抗体共享，并且可用作表型V区抗体基因标记（在参考文献3和4中综述）。Id通常由抗独特型抗体（抗Id）定义，其中Id表现为抗原并诱导产生针对自身的抗体。针对抗原的免疫应答可以通过一系列Id-抗Id反应来调节的想法首先由Niels Jerne提出（5）。这种免疫调节的网络理论提出，Id-抗Id反应通过正（增强）或负（抑制）反馈机制控制宿主对抗原的反应。Id位于抗体分子和淋巴细胞抗原受体两者的抗原结合位点上或附近，代表该网络的组分。许多研究表明Id网络参与调节对多种半抗原和蛋白质或碳水化合物抗原的免疫应答（在参考文献6和7中综述）。在抗原暴露前注射抗Id导致Id阳性抗原结合分子的抑制或Id表达和抗原结合活性的增加。许多报告表明，抗Id可用于诱导针对多种感染因子的保护性免疫（8-18）。因此，抗Ids可能代表可能的
Introduction An idiotype (Id),' or idiotypic determinant, is the antigenic portion of an antibody that encompasses the variable (V) region of the molecule. Within the V region is the site where the antigen specifically binds to the antibody. Early studies by Oudin and Michel (1) and Kunkel and co-workers (2) indicated that an Id was unique to a small set of antibody molecules. However, Ids can also be shared by antibodies specific for a given antigen and are useful as phenotypic V region antibody gene markers (reviewed in references 3 and 4). The Id is often defined by an anti-idiotypic antibody (anti-Id), whereby the Id behaves as an antigen and induces the production of antibodies against itself. The idea that the immune response to an antigen can be regulated by a series of Id-anti-Id reactions was first proposed by Niels Jerne (5). This network theory of immune regulation proposes that Id-anti-Id reactions control a host's response to an antigen via either a positive (enhancing) or negative (suppressing) feedback mechanism. Id, located on or close to the antigen binding sites of both antibody molecules and lymphocyte antigen receptors, represent components of this network. Numerous studies have implicated Id networks in regulation of the immune response to a large variety of haptens and protein or carbohydrate antigens (reviewed in references 6 and 7). The injection of anti-Id before antigen exposure has resulted in either suppression of Id-positive antigen binding molecules or increased Id expression and antigen binding activity. Numerous reports have suggested the potential use of anti-Id in the induction of protective immunity against a wide variety of infectious agents (8-18). Thus, anti-Ids may represent possi-