Comparison of nonhuman primates identified the suitable model for COVID-19
Comparison of nonhuman primates identified the suitable model for COVID-19
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DOI：
10.1038/s41392-020-00269-6
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发表时间：
2020-10-19
影响因子：
39.3
通讯作者：
Peng, Xiaozhong
中科院分区：
文献类型：
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作者：
Lu, Shuaiyao;Zhao, Yuan;Peng, Xiaozhong
识别合适的 COVID-19 非人类灵长类动物 (NHP) 模型仍然具有挑战性。在这里，我们对三种 NHP 物种中的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染进行了表征：旧世界猴猕猴 (M. mulatta) 和食蟹猴 (M. fascicularis) 以及新世界猴 Callithrix jacchus (C. jacchus)。感染者M.混血儿和M.束状胸片显示异常的胸部X光片、体温升高和体重下降。在所有动物的拭子和血液样本中均检测到病毒基因组。在 M 的肺组织中检测到病毒载量。混血儿和M.束状肌但不是 C.雅库斯。此外，在这三种动物中，M.穆拉塔对 SARS-CoV-2 表现出最强的反应，包括炎症细胞因子表达增加和肺组织病理变化。总的来说，这些数据揭示了旧世界和新世界猴子对 SARS-CoV-2 的不同易感性，并确定了 M.混血儿最适合对 COVID-19 进行建模。
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeysMacaca mulatta(M. mulatta) andMacaca fascicularis(M. fascicularis) and New World monkeyCallithrix jacchus(C. jacchus). InfectedM. mulattaandM. fascicularisshowed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues ofM. mulattaandM. fascicularisbut notC. jacchus. Furthermore, among the three animal species,M. mulattashowed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identifiedM. mulattaas the most suitable for modeling COVID-19.