Optofluidic SERS chip with plasmonic nanoprobes self-aligned along microfluidic channels
Optofluidic SERS chip with plasmonic nanoprobes self-aligned along microfluidic channels
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DOI：
10.1039/c3lc51257f
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发表时间：
2014-01-01
期刊：
影响因子：
6.1
通讯作者：
Jeong, Ki-Hun
中科院分区：
文献类型：
--
作者：
Oh, Young-Jae;Jeong, Ki-Hun
本文报道了一种具有等离子体纳米探针沿微流控通道自对准的光流SERS芯片。通过去除透明胶带和氧等离子体处理，具有丰富电磁热点的等离子体纳米探针沿着PDMS微流控通道选择性地形成图案，这也提供了PDMS和玻璃基板之间的永久结合。氧等离子体处理后，初始厚度为30 nm的银膜产生了具有最大SERS性能的纳米尖端和纳米点，并成功植入了微流控浓度梯度发生器。该新型装置能够实现无标记和溶液相的低拉曼活性小分子的SERS检测，如流动中的微摩尔水平的多巴胺。这种光流SERS芯片可以很容易地扩展到具有多种功能的微流控网络，用于先进的光学生化分析。
This work reports an optofluidic SERS chip with plasmonic nanoprobes self-aligned along microfluidic channels. Plasmonic nanoprobes with rich electromagnetic hot spots are selectively patterned along PDMS microfluidic channels by using a Scotch tape removal and oxygen plasma treatment, which also provide the permanent bonding between PDMS and a glass substrate. A silver film with an initial thickness of 30 nm after oxygen plasma treatment creates nanotips and nanodots with a maximum SERS performance, which were successfully implanted with microfluidic concentration gradient generators. The novel device enables the label-free and solution-phase SERS detection of small molecules with low Raman activity such as dopamine at micromolar level in flow. This optofluidic SERS chip can be readily expanded for microfluidic networks with diverse functions for advanced optical biochemical assays.