Graphene oxide dispersed supramolecular hydrogel capped benign green silver nanoparticles for anticancer, antimicrobial, cell attachment and intracellular imaging applications
Graphene oxide dispersed supramolecular hydrogel capped benign green silver nanoparticles for anticancer, antimicrobial, cell attachment and intracellular imaging applications
复制标题
DOI：
10.1016/j.molliq.2019.03.010
复制
发表时间：
2019-05-15
影响因子：
6
通讯作者：
Dey, B.
中科院分区：
文献类型：
--
作者：
Ghosh, D.;Dhibar, S.;Dey, B.
氧化石墨烯（GO）纳米片分散在超分子水凝胶网络（GOSHGeI）中。研究了GO分散水凝胶的微观结构。我们先前报道的良性超分子水凝胶（SHGeI）被使用并与GO的剥离单层混合，以通过几种相互作用的非共价型超分子相互作用提供GOSHGeI。采用GOSHGeI作为直接太阳光介导的光化学合成的“绿色”银纳米颗粒（Ag-NPs）的稳定剂。体外和体内毒性评估证实了GOSHGel封端的Ag-NP的生物相关性质。银纳米颗粒对细菌具有潜在的抗菌作用，包括革兰氏阴性细菌（大肠杆菌）和革兰氏阳性细菌（枯草芽孢杆菌），以及真菌病原体季也蒙毕赤酵母。值得注意的是，这些GOSHGeI加帽的Ag-NP也显示出对人乳腺癌细胞的巨大抗癌活性。GOSHGeI和包埋GOSHGeI的Ag-NPs都可用作细胞支持支架。这种细胞附着对非恶性细胞即巨噬细胞具有选择性。共聚焦显微镜研究揭示了GOSHGeI封端的银纳米粒子的发光性质。(C)2019 Elsevier B. V.版权所有。
Graphene oxide (GO) nanosheets dispersed a supramolecular hydrogel network (GOSHGeI) has been achieved. The microstructures of GO dispersed hydrogels are investigated. Our previously reported a benign supramolecular hydrogel (SHGeI) was used and mixed with exfoliated monolayers of GO to offer GOSHGeI through several interplaying non-covalent type supramolecular interactions. The GOSHGeI was employed as the stabilizing agent for the direct sun-ray mediated photo-chemically synthesized 'Green' silver nanoparticles (Ag-NPs). In vitro and in vivo toxicity assessments approve the bio-relevant nature of the GOSHGel capped Ag-NPs. The Ag-NPs were potentially antimicrobial against bacteria, including gram -ve bacterium (Escherichia coli) and gram +ve bacterium (Bacillus subtilis), and fungal pathogen, Pichia guilliermondii. Remarkably, these GOSHGeI capped Ag-NPs also showed tremendous anticancer activity tested against human breast cancer cell. Both, GOSHGeI and Ag-NPs embedded GOSHGeI, were useful as the cell supportive scaffolds. This cell attachment was selective for non-malignant cell i.e. macrophages. Confocal microscopic study revealed the luminescent nature of GOSHGeI capped Ag-NPs. (C) 2019 Elsevier B.V. All rights reserved.