Pro-posed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)
Pro-posed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)
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DOI：
10.1182/blood-2006-11-051672
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发表时间：
2007-07-15
期刊：
影响因子：
20.3
通讯作者：
Weisenburger, Dennis D.
中科院分区：
文献类型：
--
作者：
Morton, Lindsay M.;Turner, Jennifer J.;Weisenburger, Dennis D.
最近的证据表明，有不同亚型的淋巴肿瘤的病因异质性。然而，由于过去几十年来用于分类淋巴瘤和淋巴性白血病的众多临床和病理方案，已证明按疾病亚型进行流行病学分析具有挑战性。代表国际淋巴瘤流行病学联盟（InterLymph）病理学工作组，我们提出了一个建议的淋巴肿瘤的嵌套分类，以促进流行病学研究中淋巴肿瘤亚型的分析。拟议的分类基于世界卫生组织淋巴肿瘤分类和国际疾病分类-肿瘤学，第三版（ICD-O-3）。我们还提供了从以前的分类，包括工作公式，修订的欧美淋巴瘤（真实的）分类和ICD-O-2的建议分类的翻译。我们建议流行病学研究包括淋巴瘤亚型的分析，以达到样本量所允许的最详细的程度。淋巴瘤亚型流行病学研究分组的标准化对于比较文献中的亚型特异性报告，协调使用不同系统诊断的单个研究中的病例，以及合并多项研究的数据进行汇总分析或荟萃分析至关重要，并且可能被证明对于阐明各种淋巴肿瘤的病因至关重要。
Recent evidence suggests that there is etiologic heterogeneity among the various subtypes of lymphoid neoplasms. However, epidemiologic analyses by disease subtype have proven challenging due to the numerous clinical and pathologic schemes used to classify lymphomas and lymphoid leukemias over the last several decades. On behalf of the International Lymphoma Epidemiology Consortium (InterLymph) Pathology Working Group, we present a proposed nested classification of lymphoid neoplasms to facilitate the analysis of lymphoid neoplasm subtypes in epidemiologic research. The proposed classification is based on the World Health Organization classification of lymphoid neoplasms and the International Classification of Diseases-Oncology, Third Edition (ICD-O-3). We also provide a translation into the proposed classification from previous classifications, including the Working Formulation, Revised European-American Lymphoma (REAL) classification, and ICD-O-2. We recommend that epidemiologic studies include analyses by lymphoma subtype to the most detailed extent allowable by sample size. The standardization of groupings for epidemiologic research of lymphoma subtypes is essential for comparing subtype-specific reports in the literature, harmonizing cases within a single study diagnosed using different systems, as well as combining data from multiple studies for the purpose of pooled analysis or metaanalysis, and will probably prove to be critical for elucidating etiologies of the various lymphoid neoplasms.