Garland chrysanthemum consumption ameliorates age-related hearing loss in C57BL/6 mouse; model system to explore hearing loss prevention foods in a short period
Garland chrysanthemum consumption ameliorates age-related hearing loss in C57BL/6 mouse; model system to explore hearing loss prevention foods in a short period
复制标题
食用花环菊花可改善 C57BL/6 小鼠与年龄相关的听力损失；
DOI：
10.1093/bbb/zbac092
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Azami Kayo
中科院分区：
文献类型：
--
作者：
Oike Hideaki;Tomita Satoru;Koyano Hitoshi;Azami Kayo
加兰菊（Glebionis coronariaL.）是一种富含抗氧化剂的多叶蔬菜。我们发现食用加兰菊可改善C57 BL/6 J小鼠（一种早发性模型）的年龄相关性听力损失（阿勒）。我们还发现，阿勒进展显着改善了10个产品中的三个。使用核磁共振（NMR）光谱的10个产品的代谢组分析表明，植物甾醇可能参与改善阿勒。然而，植物甾醇混合物对小鼠阿勒进展的直接抑制作用尚未确定。这些结果表明，加兰菊花消费延迟阿勒发展的小鼠和其效率取决于产品的来源。本研究结果亦提示加兰菊中植物甾醇含量可作为药效的评价指标。此外，为了加速寻找预防阿勒的食物，我们使用这些数据开发了一种使用机器学习的听觉脑干反应自动阈值确定方法。
Garland chrysanthemum (Glebionis coronariaL.) is an antioxidant-rich leafy vegetable. We found that garland chrysanthemum consumption ameliorated age-related hearing loss (AHL) in C57BL/6J mice, an early onset model. We also found that AHL progression was significantly ameliorated by three of ten products. Metabolome analysis of the 10 products using nuclear magnetic resonance (NMR) spectroscopy indicated that phytosterols may be involved in the amelioration of AHL. However, the direct inhibitory effect of phytosterol mixture on mouse AHL progression was not identified. These results suggest that garland chrysanthemum consumption delays AHL development in mice and its efficiency varies depending on the source of the product. Our findings also suggest that phytosterol content in garland chrysanthemum functions as an evaluation marker for the efficiency. Furthermore, to accelerate the search for foods that prevent AHL, we have used these data to develop an automatic threshold determination method for auditory brainstem response using machine learning.