Direct Base-Assisted C-N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition-Metal-Free Conditions
Direct Base-Assisted C-N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition-Metal-Free Conditions
复制标题
无过渡金属条件下芳基卤化物与脂肪族叔胺直接碱辅助 C-N 键形成
DOI：
10.1002/ejoc.201101618
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发表时间：
2012-03-01
影响因子：
2.8
通讯作者：
Wang, Zhiyong
中科院分区：
文献类型：
--
作者：
Fang, Yang;Zheng, Yueqin;Wang, Zhiyong
在不含过渡金属的条件下，通过芳烃中间体实现了芳基卤化物与脂肪族叔胺的直接胺化反应。这种操作简单的C-N键偶联方案可以容忍各种官能化的芳基卤化物以及几种脂肪族叔胺。此外，这一环境友好的过程为直接形成C-N键提供了一种新的策略。
Direct base-mediated amination of aryl halides with aliphatic tertiary amines via an aryne intermediate was developed under transition-metal-free conditions. This operationally simple C-N bond-coupling protocol could tolerate a variety of functionalized aryl halides as well as several aliphatic tertiary amines. Moreover, this environmentally benign process provides a new strategy for direct C-N bond formation.