Enhanced sympathetic-adrenal medullary response to cold exposure in spontaneously hypertensive rats.
Enhanced sympathetic-adrenal medullary response to cold exposure in spontaneously hypertensive rats.
复制标题
自发性高血压大鼠的交感肾上腺髓质对寒冷暴露的反应增强。
DOI：
10.1097/00004872-198502000-00010
复制
发表时间：
1985
影响因子：
4.9
通讯作者：
Lovenberg,W
中科院分区：
文献类型：
--
作者：
Yamori,Y;Ikeda,K;Kulakowski,EC;McCarty,R;Lovenberg,W
为了研究自发性高血压（SHR）雄性大鼠交感-肾上腺髓质功能的调节，我们测量了4周龄和12周龄易卒中SHR（SHRSP）、卒中抵抗SHR（SHRSR）和血压正常的Wistar-Kyoto（WKY）大鼠在室温和冷暴露（4 [degree] C）期间4小时的尿儿茶酚胺排泄。冷暴露对12周龄肾上腺去神经大鼠的影响也进行了检查。在室温下，4周龄SHRSP和SHRSR大鼠尿肾上腺素排泄量显著高于同龄WKY大鼠，但去甲肾上腺素和多巴胺排泄量无显著差异。在12周龄的高血压大鼠中未观察到室温下肾上腺素排泄的增加。在冷暴露期间，尿中每种儿茶酚胺的浓度在所有三种品系的大鼠中均显著增加。此外，SHRSP大鼠肾上腺素反应显著增强，SHRSR大鼠去甲肾上腺素、肾上腺素和多巴胺反应显著增强。肾上腺去神经后，尿肾上腺素对冷暴露的反应在所有菌株中被取消。这些结果表明，增强交感神经和神经介导的肾上腺髓质反应在高血压前期SHR大鼠和更大的尿肾上腺素反应冷暴露在4和12周龄SHR大鼠。儿茶酚胺分泌的这种改变可能在这种实验性高血压的发展和维持中起重要作用。
To investigate the regulation of sympathetic-adrenal medullary function in spontaneously hypertensive (SHR) male rats, we measured urinary catecholamine excretion for 4 h at room temperature and also during cold exposure (4 [degrees] C) in groups of four and 12-week-old stroke-prone SHR (SHRSP), stroke-resistent SHR (SHRSR) and normotensive Wistar-Kyoto (WKY) rats. The effect of cold exposure on 12-week-old adrenal denervated rats was also examined. At room temperature, urinary excretion of epinephrine, but not norepinephrine or dopamine, was increased significantly in four-week-old SHRSP and SHRSR rats compared with age-matched WKY. The enhanced excretion of epinephrine at room temperature was not observed in hypertensive rats at 12 weeks of age. During cold exposure, urinary concentrations of each catecholamine increased markedly in rats of all three strains. In addition, the epinephrine response was significantly enhanced in SHRSP rats and the norepinephrine, epinephrine and dopamine responses were significantly enhanced in SHRSR rats. Following adrenal denervation, the urinary epinephrine response to cold exposure was abolished in all strains. These results reveal an enhancement of sympathetic and neurally-mediated adrenal medullary responses in prehypertensive SHR rats and a greater urinary epinephrine response to cold exposure in four and 12-week-old SHR rats. This alteration in catecholamine secretion may be important in the development and maintenance of this type of experimental hypertension.