PROGNOSTIC SIGNIFICANCE OF P16 IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK TREATED WITH CONCURRENT CISPLATIN AND RADIOTHERAPY
PROGNOSTIC SIGNIFICANCE OF P16 IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK TREATED WITH CONCURRENT CISPLATIN AND RADIOTHERAPY
复制标题
DOI：
10.1002/hed.21439
复制
发表时间：
2011-02-01
影响因子：
2.9
通讯作者：
Magliocco, Anthony M.
中科院分区：
文献类型：
--
作者：
Lau, Harold Y.;Brar, Sony;Magliocco, Anthony M.
背景人乳头瘤病毒（HPV）相关的头颈部鳞状细胞癌（SCCHN）已成为一个独特的临床实体。p16蛋白的表达可作为HPV感染状态的替代指标。p16免疫组化（IHC）在档案石蜡包埋材料进行了评估，55例局部晚期SCCHN与顺铂和放射治疗的统一方案。采用比色原位杂交（CISH）和聚合酶链反应（PCR）检测HPV感染情况。与p16和HPV阴性患者相比，p1.6和HPV阳性患者的总生存率、无病生存率和局部复发率均有所提高。p16免疫组化可作为一个有用的替代和预后标志物与HPV相关的SCCHN患者顺铂和放射治疗。(C)2010 Wiley Periodicals，Inc.头颈部33：251-256，2011
Background. Human papillomavirus (HPV)related squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status.Methods. p16 immunohistochemistry (IHC) was assessed in archival paraffin-embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation. HPV status was assessed by colorimetric in situ hybridization (CISH) and polymerase chain reaction (PCR).Results. Compared with p16- and HPV-negative patients, the p1.6- and HPV-positive patients had improved overall survival, disease-free survival, and locoregional recurrence rates.Conclusions. p16 IHC may serve as a useful surrogate and prognostic marker for patients with HPV-related SCCHN treated with cisplatin and radiation. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 251-256, 2011