Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia
Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia
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DOI：
10.1016/j.jri.2012.11.006
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发表时间：
2013-04-01
影响因子：
3.4
通讯作者：
Woodruff, Trent M.
中科院分区：
文献类型：
--
作者：
Denny, Kerina J.;Coulthard, Liam G.;Woodruff, Trent M.
先兆子痫是世界范围内发病率和死亡率的主要原因，包括显著的短期和长期健康后遗症。最近，有越来越多的证据表明补体系统在许多妊娠并发症（包括先兆子痫）的发病机制中发挥作用。本横断面研究比较了血压正常的妊娠和合并先兆子痫或妊娠期高血压的妊娠之间补体因子C3a和C5a的血浆浓度。我们发现，母亲血浆C5a浓度显着高于先兆子痫妊娠比妊娠高血压或正常妊娠。与妊娠期高血压或血压正常的妊娠相比，合并先兆子痫的妊娠脐带血浆C5a浓度也更高。母体和脐带血浆C5a浓度显著相关，表明C5a可以在母体和胎儿循环之间自由扩散。任何组之间母体或脐带血浆中的C3a浓度均无显著差异。这些结果支持C5a可能在先兆子痫中发挥作用，但在妊娠高血压中不起作用的假设。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Preeclampsia is a leading cause of morbidity and mortality worldwide, encompassing significant short- and long-term health sequelae. Recently, there has been accumulating evidence for a role of the complement system in the pathogenesis of numerous complications of pregnancy, including preeclampsia. The present cross-sectional study compared the plasma concentrations of complement factors C3a and C5a between normotensive pregnancies and pregnancies complicated with either preeclampsia or gestational hypertension alone. We found that maternal plasma C5a concentration was significantly higher in preeclamptic pregnancy than in pregnancy affected by gestational hypertension alone or normotensive pregnancy. Umbilical cord plasma C5a concentrations were also higher in pregnancies complicated by preeclampsia compared to gestational hypertension or normotensive pregnancy. Maternal and cord plasma C5a concentrations were significantly correlated, suggesting that C5a can freely diffuse between maternal and fetal circulation. There were no significant differences in C3a concentrations in maternal or cord plasma between any groups. These results support the hypothesis that C5a may play a role in preeclampsia, but not in gestational hypertension. (C) 2013 Elsevier Ireland Ltd. All rights reserved.