URINARY-BLADDER AND URETHRAL RESPONSES TO PELVIC AND HYPOGASTRIC NERVE-STIMULATION AND THEIR RELATION TO VASOACTIVE INTESTINAL POLYPEPTIDE IN THE ANESTHETIZED DOG
URINARY-BLADDER AND URETHRAL RESPONSES TO PELVIC AND HYPOGASTRIC NERVE-STIMULATION AND THEIR RELATION TO VASOACTIVE INTESTINAL POLYPEPTIDE IN THE ANESTHETIZED DOG
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DOI：
10.1111/j.1748-1716.1990.tb08864.x
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发表时间：
1990-03-01
期刊：
影响因子：
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通讯作者：
UVNASMOBERG, K
中科院分区：
文献类型：
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作者：
ANDERSSON, PO;SJOGREN, C;UVNASMOBERG, K
研究了麻醉犬膀胱、尿道盆腔和胃下神经刺激的作用及其与血管活性肠多肽（VIP）的关系。盆腔和胃下神经刺激均引起膀胱血流量的两倍增加和膀胱静脉流出物VIP浓度的明显增加。胃下神经刺激引起最初的部分α。-肾上腺素能和部分非肾上腺素能，非胆碱能，膀胱收缩，随后放松。尿道反应维持在。α。肾上腺素收缩。盆腔神经刺激引起膀胱收缩，最初有一个非胆碱能峰值，随后膀胱压力维持在较低水平，这一效应主要是源于胆碱能。尿道反应最初为非肾上腺素能性、非胆碱能性收缩，随后维持胆碱能性收缩反应。传入骨盆神经刺激导致传出活动，似乎是骨盆和胃下通路到膀胱和尿道的活动的组合。静脉注射VIP （10 nmol）引起膀胱和尿道松弛，同时全身血压下降。然而，尽管血浆浓度高，膀胱没有引起血管舒张。因此，盆腔和胃下神经刺激时VIP释放的主要目标可能不是膀胱血管，而是膀胱平滑肌本身。
The effects of the urinary bladder and urethra of pelvic and hypogastric nerve stimulation and their relation to vasoactive intestinal polypeptides (VIP) were investigated in the anaesthetized dog. Both pelvic and hypogastric nerve stimulation elicited a twofold increase in urinary bladder blood flow and a clear-cut increase in bladder venous effluent VIP concentration. Hypogastric nerve stimulation induced an initial, partly .alpha.-adrenergic and partly non-adrenergic, non-cholinergic, contraction of the urinary bladder followed by a relaxation. The urethra response was a maintained .alpha.-adrenergic contraction. Pelvic nerve stimulation elicited a bladder contraction with an initial non-cholinergic peak, whereafter the bladder pressure was maintained at a lower level, an effect which was mainly cholinergic in origin. The urethral response was an initial non-adrenergic, non-cholinergic contraction followed by a maintained cholinergic contractile response. Afferent pelvic nerve stimulation led to an efferent activity that seemed to be a combination of activity in pelvic and hypogastric pathways to the urinary bladder and the urethra. VIP (10 nmol) injected i.v. induced a relaxation of the urinary bladder and the urethra, together with a fall in systemic blood pressure. However, despite high plasma concentrations, no vasodilation was elicited in the urinary bladder. Thus, the main target for the VIP release during pelvic and hypogastric nerve stimulation is probably not the bladder vasculature, but instead perphaps the bladder smooth muscle proper.