Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells.
Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells.
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DOI：
10.15252/embr.202051716
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发表时间：
2023-06-05
期刊：
影响因子：
7.7
通讯作者：
中科院分区：
文献类型：
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目前的证据表明，半胱天冬酶激活与基本细胞功能的调节有关，而不引起细胞凋亡。非凋亡半胱天冬酶活性的功能障碍可能导致特定的神经系统疾病、代谢疾病、自身免疫性疾病和癌症。然而，我们对非凋亡caspase功能的理解仍然有限。在这里，我们发现非凋亡caspase激活阻止了自噬体中Patched受体的细胞内积累以及随后的果蝇滤泡干细胞中Patched依赖性自噬诱导。这些事件最终维持刺猬信号和生理特性的卵巢体干细胞及其后代在中度热应激。重要的是，我们的关键发现在人类起源的卵巢体细胞中部分保守。这些观察结果归因于胱天蛋白酶在某些细胞条件下的促生存作用。半胱天冬酶的非凋亡激活通过调节自噬和Hedgehog（Hh）信号传导维持中度热应激下卵巢体细胞的细胞增殖和分化。
Current evidence has associated caspase activation with the regulation of basic cellular functions without causing apoptosis. Malfunction of non‐apoptotic caspase activities may contribute to specific neurological disorders, metabolic diseases, autoimmune conditions and cancers. However, our understanding of non‐apoptotic caspase functions remains limited. Here, we show that non‐apoptotic caspase activation prevents the intracellular accumulation of the Patched receptor in autophagosomes and the subsequent Patched‐dependent induction of autophagy in Drosophila follicular stem cells. These events ultimately sustain Hedgehog signalling and the physiological properties of ovarian somatic stem cells and their progeny under moderate thermal stress. Importantly, our key findings are partially conserved in ovarian somatic cells of human origin. These observations attribute to caspases a pro‐survival role under certain cellular conditions. Non‐apoptotic activation of caspases sustains cell proliferation and differentiation in ovarian somatic cells under moderate thermal stress by modulating autophagy and Hedgehog (Hh)‐signalling.
DOI：
10.1083/jcb.201212094
发表时间：
2013-05-27
期刊：
The Journal of cell biology
影响因子：
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作者：
Hartman TR;Strochlic TI;Ji Y;Zinshteyn D;O'Reilly AM
通讯作者：
O'Reilly AM