[Search for alternative secondary structures of RNA, regulating expression of bacterial genes].
[Search for alternative secondary structures of RNA, regulating expression of bacterial genes].
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[寻找RNA的替代二级结构，调节细菌基因的表达]。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
V. A. Liubetskiĭ
中科院分区：
文献类型：
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作者：
E. V. Liubetskaia;L. A. Leont'ev;M. S. Gel’fand;V. A. Liubetskiĭ
许多细菌基因的表达是通过前导 mRNA 序列内替代二级 RNA 结构的形成来调节的。我们设计用于搜索这些结构的算法（基于对一个核苷酸序列的分析）被应用于分析α-和γ-变形菌中氨基酸生物合成的操纵子。预测了一些鲜为人知的γ-变形菌（包括腐败希瓦氏菌）的基因组中这些操纵子的弱化子，还预测了一些α-变形菌中色氨酸操纵子的弱化子。
Expression of many bacterial genes is regulated by formation of alternative secondary RNA structure within the leader mRNA sequence. Our algorithm designed to search for these structures (basing on analysis of one nucleotide sequence) was applied to analyze operons of amino acid biosynthesis in alpha- and gamma-proteobacteria. The attenuators of these operons are predicted for genomes of some poorly known gamma-proteobacteria including Shewanella putrefaciens, attenuators of the tryptophan operon in some alpha-proteobacteria are also predicted.