Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.
Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.
复制标题
干燥综合征唾液腺微环境中细胞粘附分子的表达。
DOI：
10.1002/art.1780350110
复制
发表时间：
1992
影响因子：
--
通讯作者：
Kay H. Singer
中科院分区：
文献类型：
--
作者：
E. William S.T. Clair;John C. Angellilo;Kay H. Singer
目的
通过检测细胞粘附分子在唾液腺（SGL）组织中的表达，评估了细胞粘附分子在干燥综合征（SS）发病机制中的潜在作用。
方法
采用间接免疫荧光技术测定细胞间粘附分子1（ICAM-1）、淋巴细胞功能相关抗原1（LFA-1）、LFA-3、CD 2和CD 44的表达。
结果
在发炎的唇SGL组织中，ICAM-1表达在浸润的LFA-1+/CD 2 +/LFA-3+单核细胞上是明显的，并且在有限程度上在邻近强烈炎症部位的SGL腺泡上皮细胞上是明显的。
结论
在SS中，SGL微环境的特征在于上皮细胞上ICAM-1表达的仅适度上调，尽管存在具有活化表型的T细胞。
OBJECTIVE
The potential role of cell adhesion molecules in the pathogenesis of Sjögren's syndrome (SS) was assessed by examining their expression in salivary gland (SGL) tissue.
METHODS
Intercellular adhesion molecule type 1 (ICAM-1), lymphocyte function-associated antigen type 1 (LFA-1), LFA-3, CD2, and CD44 expression were determined using indirect immunofluorescence techniques.
RESULTS
In inflamed labial SGL tissue, ICAM-1 expression was evident on infiltrating LFA-1+/CD2+/LFA-3+ mononuclear cells, and to a limited extent on SGL acinar epithelial cells adjacent to sites of intense inflammation.
CONCLUSION
In SS, the SGL microenvironment is characterized by only a modest up-regulation of ICAM-1 expression on epithelial cells, despite the presence of T cells bearing an activated phenotype.
影响因子：
4.4
作者：
Michael Loran Dustin;R. Rothlein;A. Bhan;C. Dinarello;T. Springer
通讯作者：
Michael Loran Dustin;R. Rothlein;A. Bhan;C. Dinarello;T. Springer