The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning.
The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning.
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缺血性后的保护作用反对中风：从迅速到延迟和远程后的调节。
DOI：
10.2174/1877381801002010138
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发表时间：
2011-12-24
期刊：
影响因子：
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通讯作者：
Zhao H
中科院分区：
文献类型：
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作者：
Zhao H
作者综述了缺血后处理的保护作用，这是一种新出现的策略，在寻找中风和心肌缺血损伤的新治疗方法方面具有广泛的意义。缺血后处理是指在缺血器官再灌流后立即在缺血器官部位进行一系列短暂的缺血和再灌注循环，从而减少脑和心肌缺血的梗塞。再灌流后几分钟内诱发的常规后处理可任意定义为快速后处理。相反，卒中后数小时至数天进行的后处理被定义为延迟后处理。此外，可以使用麻醉药或其他药物作为刺激来模拟后处理，以防止缺血/再灌注损伤，或者在远处器官进行后处理，这被称为远程后处理。在本文中，作者讨论了经典的快速缺血后处理的概念起源，以及它演变成一个代表广泛刺激或触发的术语，包括延迟后处理、药理学后处理和远程后处理。然后，对后处理的各种体内和体外模型及其可能的保护机制进行了讨论。由于后处理的概念与预处理的概念密切相关，并且两者共享一些共同的保护机制，因此本文还讨论了预处理和后处理的组合是否比预处理或单独的后处理提供更大的保护。
The author reviews the protective effects of ischemic postconditioning, a recently emerging strategy with broad implications in the search for new treatments in stroke and myocardial ischemic injury. Ischemic postconditioning, which refers to a series of brief ischemia and reperfusion cycles applied immediately at the site of the ischemic organ after reperfusion, results in reduced infarction in both cerebral and myocardial ischemia. Conventional postconditioning induced within a few minutes after reperfusion is arbitrarily defined as rapid postconditioning. In contrast, postconditioning performed hours to days after stroke is defined as delayed postconditioning. In addition, postconditioning can be mimicked using anesthetics or other pharmacological agents as stimuli to protect against ischemia/reperfusion injury or performed in a distant organ, which is known as remote postconditioning. In this article, the author discusses the conceptual origin of classical rapid ischemic postconditioning and its evolution into a term that represents a broad range of stimuli or triggers, including delayed postconditioning, pharmacological postconditioning, and remote postconditioning. Thereafter, various in vivo and in vitro models of postconditioning and its potential protective mechanisms are discussed. Since the concept of postconditioning is so closely associated with that of preconditioning and both share some common protective mechanisms, whether a combination of preconditioning and postconditioning offers greater protection than preconditioning or postconditioning alone is also discussed.