Nitrite/nitrate oxide and cytokines changes in patients with surgical stress
Nitrite/nitrate oxide and cytokines changes in patients with surgical stress
复制标题
DOI：
10.1007/s10620-005-2661-2
复制
发表时间：
2005-05-01
影响因子：
3.1
通讯作者：
Yamaue, H
中科院分区：
文献类型：
--
作者：
Hirabayashi, N;Tanimura, H;Yamaue, H
诱导型一氧化氮合酶（inducible nitric oxide synthase，iNOS）产生的一氧化氮（Nitric oxide，NO）参与免疫和炎症过程。炎性细胞因子和内毒素诱导各种细胞产生大量NO。手术应激产生细胞因子，导致全身炎症反应综合征（SIRS）。细胞因子的持续大量产生导致多种并发症，包括肺炎、腹腔脓肿和败血症。我们调查了50例胃肠外科手术患者的亚硝酸盐/硝酸盐（NOx）浓度和细胞因子水平之间的关系。我们检测了细胞因子的水平，包括白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）（TNF-α）白细胞介素-1受体拮抗剂（IL-1 ra），和亚硝酸盐/硝酸盐（NOx）目的：检测50例胃肠外科手术患者血清及胸腹腔渗出液中细胞因子浓度，探讨血清中细胞因子与NO、NOx水平的关系有并发症组在第3、7天较无并发症组高（P < 0.05）。并发症组IL-6升高更明显，NOx水平同步升高。总之，手术应激引起炎性细胞因子血症。在手术应激期间产生NOx，并且当并发症发生时，产生更多的NOx。
Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) is implicated in immunolog-ical and inflammatory processes. Inflammatory cytokines and endotoxin induce a large amount of NO from various cells. Surgical stress produces cytokines, which leads to systemic inflammatory response syndrome (SIRS). Continuously high production of cytokines causes a variety of complications including pneumonia, intraabdominal abscess and sepsis. We investigated the relationships between the nitrite/nitrate (NOx) concentration and the level of cytokines in 50 patients undergoing gastroenterological surgery. We measured the levels of cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) interleukin-1 receptor antagonist (IL- 1ra), and nitrite/nitrate (NOx) concentration in the serum and exudative fluid from the thoracic or abdominal cavity of 50 patients undergoing gastroenterological surgery in order to make clear the relationship between cytokines and NO.NOx levels in the serum of the group with complications were higher on days 3 and 7 than in the group with no complications (P < 0.05). In the complications group, IL-6 was more elevated, and the NOx level was synchronously elevated. In conclusion, surgical stress caused inflammatory cytokinemia. NOx was produced during surgical stress, and when complications occurred, more NOx was produced.