Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study
Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study
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DOI：
10.1111/j.1365-2265.2006.02560.x
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发表时间：
2006-07-01
影响因子：
3.2
通讯作者：
McKinlay, John B.
中科院分区：
文献类型：
--
作者：
Derby, Carol A.;Zilber, Sophia;McKinlay, John B.
目的横断面数据显示，肥胖，尤其是中心性肥胖，可能与男性性激素分泌减少有关。然而，关于男性肥胖状况的纵向激素数据是有限的。之前的研究并没有始终如一地证明性类固醇是否与体重指数或中心性肥胖指标有明确的关联。我们的目标是研究肥胖(体重指数和30公斤/米(2))和中心性肥胖(腰围和腰臀比和腰臀比和腰围和臀围；在马萨诸塞州的男性老龄化研究中，942名男性患者在基线(1987年-1989年，年龄40-70岁)和随访(1995年-1997年)时有完整的人体测量和激素数据。测量游离和总睾酮(FT和TT)、脱氢表雄酮硫酸盐(DHEAS)和性激素结合球蛋白(HBG)采用标准化方法进行评估。通过结构化访谈获得健康行为和病史。采用重复测量回归方法描述类固醇激素和SHBG与肥胖状态的关系，调整年龄、吸烟、饮酒、合并症和体力活动。结果与基线相比，肥胖与总睾酮和游离睾酮水平以及SHBG水平下降相关。对于任何给定的TT、FT或SHBG基线浓度，在继续肥胖或在随访期间变得肥胖的男性中，随访水平最低。肥胖症的三个指标都是如此。中心性肥胖与随访时较低的DHEAS水平相关，而体重指数升高则不相关。结论肥胖可能预示着随着年龄的增长，睾酮和SHBG水平下降更大。中心性肥胖可能是DHEAS下降的一个比体重指数更重要的预测指标。
Objective Cross-sectional data suggest that obesity, particularly central obesity, may be associated with decreased production of sex steroid hormones in men. However, longitudinal hormone data on men in relation to obesity status are limited. Previous studies have not consistently demonstrated whether sex steroids are associated specifically to body mass index or to measures of central obesity. Our objective was to examine the relation of obesity (body mass index > 30 kg/m(2)), and of central obesity (waist circumference > 100 cm or waist to hip ratio > 0.95) to longitudinal change in sex steroid hormones in men.Design Prospective follow-up of a population-based sample of men in Boston.Patients Nine hundred forty-two (942) men in the Massachusetts Male Ageing Study with complete anthropometry and hormone data at baseline (1987-1989, ages 40-70) and follow-up (1995-1997).Measurements Free and total testosterone (FT and TT), dehydroepiandrosterone sulphate (DHEAS), and sex hormone-binding globulin (SHBG) were assessed using standardized methods. Health behaviours and medical history were obtained by structured interview. Repeated measures regression was used to describe trends in steroid hormones and SHBG in relation to obesity status, adjusting for age, smoking, alcohol, comorbidities, and physical activity.Results Obesity was associated with decreased levels of total and free testosterone, and of SHBG at follow-up relative to baseline. For any given baseline concentration of TT, FT or SHBG, follow-up levels were lowest among men who remained obese or who became obese during follow-up. This was true for all three indices of obesity. Central adiposity was associated with lower DHEAS levels at follow-up, while elevated body mass index was not.Conclusions Obesity may predict greater decline in testosterone and SHBG levels with age. Central adiposity may be a more important predictor of decline in DHEAS than is body mass index.