COGNITIVE IMPAIRMENT AND MORTALITY - A STUDY OF POSSIBLE CONFOUNDERS
COGNITIVE IMPAIRMENT AND MORTALITY - A STUDY OF POSSIBLE CONFOUNDERS
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DOI：
10.1093/oxfordjournals.aje.a115625
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发表时间：
1990-07-01
影响因子：
5
通讯作者：
WOLF, PA
中科院分区：
文献类型：
--
作者：
LIU, IY;LACROIX, AZ;WOLF, PA
对2123名弗雷明翰心脏研究参与者的基线神经心理功能进行了评估，并与8年至10年的随访期死亡率有关。在此期间，有573人死亡。使用COX比例风险模型，作者表明认知功能差与死亡风险的增加一致相关。在对年龄、教育程度和疾病的混杂影响进行调整后，这种关联仍然存在。与高分相比，得分低于第26个百分位数的受试者死亡风险更高(第11个百分位数-第25个百分位数-第25个百分位数的相对风险为1.3，第1个百分位数-第10个百分位数的相对风险为1.7)。
Baseline neuropsychological function was assessed in 2,123 Framingham Heart Study participants and was related to mortality over an 8- to 10-year follow-up period. During that time, 573 persons died. Using Cox proportional hazards models, the authors showed poor cognitive function to be consistently associated with an increased risk of death. This association persisted after adjustment for the confounding effects of age, education, and illness. Subjects scoring below the 26th percentile of performance were at increased risk of mortality compared with high scores (the relative risk was 1.3 for the 11th percentile-25th percentile-25th percentile and 1.7 for the 1st percentile-10th percentile).