Systemic lupus erythematosus: considerations for a genetic approach.
Systemic lupus erythematosus: considerations for a genetic approach.
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DOI：
10.1038/jid.1994.27
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发表时间：
1994-11
期刊：
影响因子：
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通讯作者：
J. Harley;P. Sheldon;B. Neas;S. Murphy;D. Wallace;R. Scofield;T. Shaver;K. Moser
中科院分区：
文献类型：
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作者：
J. Harley;P. Sheldon;B. Neas;S. Murphy;D. Wallace;R. Scofield;T. Shaver;K. Moser
有有力的证据表明，系统性红斑狼疮的病因和发病机制有遗传和环境因素。不幸的是，了解狼疮的遗传学一直受到了解遗传模式的阻碍。事实上，狼疮疾病的已知特征提示了这种疾病表型的复杂遗传方式。25个多发性狼疮家系已被纳入，并已被用来评估权力，揭示连锁。在这些家系中发现常染色体隐性遗传的连锁的能力比常染色体显性遗传的要大。一旦有100个相似的谱系可供选择，
There is powerful evidence suggesting that etiology and pathogenesis of systemic lupus erythematosus has both genetic and environmental components. U nfor tunately, understanding the genetics of lupus has been impeded by knowing the pattern of inheritance. In deed, a complex mode of inheritance for the lupus dis ease phenotype is suggested by the known characteris tics of this disorder. Twenty-five multiplex pedigrees for lupus have been enrolled and have been used to evaluate power to reveal linkage. The power to find linkage in these pedigrees is greater for autosomal re cessive than for autosomal dominant modes of inheri tance. Once 100 similar pedigrees are available for