A rapid brain metabolic change in infants detected by fMRI
A rapid brain metabolic change in infants detected by fMRI
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DOI：
10.1097/00001756-199712010-00024
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发表时间：
1997-12
期刊：
影响因子：
1.7
通讯作者：
Hiroki Yamada;N. Sadato;Y. Konishi;K. Kimura;Masato Tanaka;Yoshiharu Yonekura;Yasushi Ishii
中科院分区：
文献类型：
--
作者：
Hiroki Yamada;N. Sadato;Y. Konishi;K. Kimura;Masato Tanaka;Yoshiharu Yonekura;Yasushi Ishii
为了确定人类视皮层活动相关代谢的发育变化，我们从新生儿期开始进行了功能磁共振成像(FMRI)。光刺激下的fMRI显示了伴随着正常人脑成熟的快速代谢变化模式。大于8周的婴儿在视觉皮质中表现出与刺激相关的信号减少，而较小的新生儿则表现出信号增加。婴儿的这种反应倒置表明，神经元激活过程中的氧耗发生了变化，这与突触的快速形成和伴随的新陈代谢增加有关。功能磁共振成像可以检测大脑成熟过程中的动态代谢变化，为检测大脑发育异常或中枢神经系统的可塑性提供了新的线索。
TO determine developmental changes of activity-related metabolism in human visual cortex, we performed functional magnetic resonance imaging (fMRI) from the neonatal period. A rapid metabolic changing pattern accompanying normal human brain maturation was revealed by fMRI with photic stimulation. Infants older than 8 weeks of age showed a stimulus-related signal decrease in the visual cortex, whereas younger neonates showed a signal increase. This inversion of response in infants suggests a change in oxygen consumption during neuronal activation, which is related to rapid synapse formation and accompanying increased metabolism. fMRI can detect dynamic metabolic changes during the brain maturation, and provides a new clue in the detection of abnormal brain development or CNS plasticity.