Bone-crack detection, targeting, and repair using ion gradients.
Bone-crack detection, targeting, and repair using ion gradients.
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DOI：
10.1002/anie.201305759
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发表时间：
2013-10-11
期刊：
影响因子：
--
通讯作者：
Sen A
中科院分区：
文献类型：
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作者：
Yadav V;Freedman JD;Grinstaff M;Sen A
在过去十年中，由于基本电机设计和功能的进步，自供电纳米电机和泵越来越多地被探索用于生物应用。[1]这种不需要外部电源的自主设备提供了广泛的潜在生物医学应用，从靶向药物输送到微创手术。离子梯度可以引起流体和颗粒的扩散电泳运输，并提供一种用于将运动导向特定目标的方法。我们在这里描述了一种基于生物合成混合微泵的策略，通过利用受损基质本身作为触发器和燃料来检测骨病变。高矿物质含量材料（如骨骼）中的裂缝会产生离子梯度驱动的电场，可用于主动靶向和治疗。电场和随后的电泳作为运动细胞定向运动的机制的作用最近也得到了说明。[2]我们的策略也适用于合成表面具有相同的效率。
Self-powered nanomotors and pumps are increasingly being explored for biological applications given the advances in basic motor design and functionality over the last decade.[1] Such autonomous devices, requiring no external power supply, offer a broad range of potential biomedical applications ranging from targeted drug delivery to minimally invasive surgeries. Ion gradients can cause diffusiophoretic transport of fluid and particles and provide one method for directing movement towards specific targets. We describe here a strategy based on a biological synthetic hybrid micropump for the detection of bone lesions by utilizing the damaged matrix itself as both the trigger and the fuel. A crack in a high-mineral-content material, such as bone, generates ion-gradient-driven electric fields, which can be utilized for active targeting and treatment. The role of electric fields and ensuing electrophoresis as a mechanism for the directional movement of motile cells has also recently been illustrated.[2] Our strategy is also applicable to synthetic surfaces with equal efficiency.