Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes To Form Nitriles
Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes To Form Nitriles
复制标题
有氧铜促进配位氰化物阴离子的自由基型裂解：氮转移至醛形成腈
DOI：
10.1021/jacs.5b10945
复制
发表时间：
2016
影响因子：
15
通讯作者：
You Jingsong
中科院分区：
文献类型：
--
作者：
Wu Qian;Luo Yi;Lei Aiwen;You Jingsong
我们首次公开了铜促进的配位氰根阴离子在氧气气氛下的C--N三键断裂，这使得氮转移到各种醛上。对这一史无前例的转变的机制研究表明，单电子转移过程可能参与了整个过程。该方案为氰离子提供了一种新的切割模式，并最终将导致从醛到腈的更有用的合成途径。
We have disclosed for the first time the copper-promoted CN triple bond cleavage of coordinated cyanide anion under a dioxygen atmosphere, which enables a nitrogen transfer to various aldehydes. Mechanistic study of this unprecedented transformation suggests that the single electron-transfer process could be involved in the overall course. This protocol provides a new cleavage pattern for the cyanide ion and would eventually lead to a more useful synthetic pathway to nitriles from aldehydes.