Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology
Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology
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DOI：
10.1038/npp.2015.344
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发表时间：
2016-06-01
影响因子：
7.6
通讯作者：
Tendolkar, Indira
中科院分区：
文献类型：
--
作者：
Everaerd, Daphne;Klumpers, Floris;Tendolkar, Indira
儿童期逆境（CA）与长期的大脑结构改变和精神疾病风险增加有关。有证据表明，CA的亚型，不同的威胁和剥夺的维度，导致不同的神经和行为结果。然而，这些特定的关联尚未建立，没有潜在的混杂因素，如精神病理学。此外，神经发育和精神病理学的差异需要探索性二态性。根据大型数据库中的CA病史选择年轻健康成年受试者，以评估与逆境特定亚型相关的灰质（GM）差异。我们比较了基于体素的受试者报告特定的儿童期暴露于虐待（n = 127）或剥夺（n = 126）和一个类似规模的对照组（n = 129）没有报告CA的形态测量数据。受试者在年龄、性别和教育水平上相匹配。CA亚型之间的差异被发现在梭状回和中枕回，其中与滥用史的受试者相比，剥夺史的受试者表现出减少GM。性别和CA亚型之间存在交互作用，女性在两种亚型CA后视觉楔前区的GM均低于对照组。与虐待相比，在童年被剥夺后，男性在中央后体育馆中的GM较少。我们的研究结果表明，即使在健康人群中，CA亚型也与大脑结构的特定改变有关，这些改变受到性别的调节。这些发现可能有助于理解与CA相关的神经发育后果。
Childhood adversity (CA) has been associated with long-term structural brain alterations and an increased risk for psychiatric disorders. Evidence is emerging that subtypes of CA, varying in the dimensions of threat and deprivation, lead to distinct neural and behavioral outcomes. However, these specific associations have yet to be established without potential confounders such as psychopathology. Moreover, differences in neural development and psychopathology necessitate the exploration of sexual dimorphism. Young healthy adult subjects were selected based on history of CA from a large database to assess gray matter (GM) differences associated with specific subtypes of adversity. We compared voxel-based morphometry data of subjects reporting specific childhood exposure to abuse (n = 127) or deprivation (n = 126) and a similar sized group of controls (n = 129) without reported CA. Subjects were matched on age, gender, and educational level. Differences between CA subtypes were found in the fusiform gyrus and middle occipital gyms, where subjects with a history of deprivation showed reduced GM compared with subjects with a history of abuse. An interaction between sex and CA subtype was found. Women showed less GM in the visual posterior precuneal region after both subtypes of CA than controls. Men had less GM in the postcentral gyms after childhood deprivation compared with abuse. Our results suggest that even in a healthy population, CA subtypes are related to specific alterations in brain structure, which are modulated by sex. These findings may help understand neurodevelopmental consequences related to CA.