Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis
Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis
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DOI：
10.1902/jop.1998.69.12.1419
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发表时间：
1998-12-01
影响因子：
4.3
通讯作者：
Cochran, D
中科院分区：
文献类型：
--
作者：
Graves, DT;Delima, AJ;Cochran, D
牙周病是人类牙齿脱落的重要原因，也是与骨丢失相关的最常见疾病之一。细菌定植后，牙龈发炎，在某些情况下，发展到牙槽骨的破坏。为了研究炎症细胞向牙槽骨的时间运动以及白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）在此过程中的作用，在实验性牙周炎的食蟹猴灵长类动物模型中进行了研究。IL-1和TNF活性抑制局部应用可溶性受体IL-1和TNF注射到牙间乳头。结果表明，诱导实验性牙周炎后，炎症细胞的前沿向牙槽骨方向发展，并与破骨细胞的形成有关。这些过程被IL-1和TNF的阻断剂抑制。这些研究表明，从牙龈炎到牙周炎的转化与炎性浸润物向牙槽骨的移动直接相关，并且这种活性至少部分依赖于IL-1和/或TNF。
PERIODONTAL DISEASE IS A SIGNIFICANT cause of tooth loss in humans and is one of the most prevalent diseases associated with bone loss. Following bacterial colonization, the gingiva becomes inflamed and, in some cases, progresses to destruction of alveolar bone. To investigate the temporal movement of inflammatory cells toward alveolar bone and the role of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in this process, studies were carried out in a Macaca fascicularis primate model of experimental periodontitis. IL-1 and TNF activity was inhibited by local application of soluble receptors to IL-1 and TNF by injection into interdental papillae. The results indicate that following induction of experimental periodontitis, the front of inflammatory cells progresses toward alveolar bone and is associated with osteoclast formation. These processes are inhibited by blockers to IL-1 and TNF. These studies suggest that the conversion from gingivitis to periodontitis is directly associated with the movement of an inflammatory infiltrate toward alveolar bone, and that this activity is at least partially dependent upon IL-1 and/or TNF.