Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia
Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia
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DOI：
10.1038/bmt.2009.378
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发表时间：
2010-10-01
影响因子：
4.8
通讯作者：
Kojima, S.
中科院分区：
文献类型：
--
作者：
Yagasaki, H.;Takahashi, Y.;Kojima, S.
从1991年1月至2007年3月，61名儿童和青少年获得性重型再生障碍性贫血在我院接受骨髓移植。我们回顾性比较了30例同胞骨髓移植（MSD-BMT）和31例非血缘骨髓移植（URD-BMT）的结果。我们观察到MSD-BMT受体中有1例移植失败，URD-BMT受体中有3例移植失败。MSD-BMT组中没有患者发生II-IV级急性GVHD，而URD-BMT组中有11例（37%）发生急性GVHD（P <0.001）。30例MSD-BMT接受者中有1例（3%）发生慢性GVHD，而URD-BMT接受者中有8例（27%）发生慢性GVHD（P = 0.013）。EBV和CMV再激活的发生率分别为20例URD-BMT受者中的11例和30例中的23例。URD-BMT组1例患者在BMT后5.5年死于车祸。MSD-BMT接受者和URD-BMT接受者的10年OS分别为100%和93.8%（95%CI，81.9 - 100%）（P = 0.252）。MSD-BMT组和URD-BMT组的10年无失败生存率分别为96.7%（95%CI，90.2 - 100%）和84.7%（95%CI，70.2 - 99.2%）（P = 0.161）。骨髓移植（2010）45，1508 - 1513; doi：10.1038/bmt.2009.378; 2010年2月1日在线发表
From January 1991 to March 2007, 61 children and adolescent with acquired severe aplastic anemia received BMT in our institutions. We retrospectively compared the outcome of 30 cases of matched-sibling donor BMT (MSD-BMT) and 31 cases of unrelated donor BMT (URD-BMT). We observed one graft failure among MSD-BMT recipients and three graft failures among URD-BMT recipients, respectively. No patients in the MSD-BMT group developed grades II-IV acute GVHD compared with 11 of 30 patients (37%) in the URD-BMT group (P < 0.001). One of 30 MSD-BMT recipients (3%) developed chronic GVHD compared with 8 of 30 URD-BMT recipients (27%) (P = 0.013). The incidence of EBV and CMV reactivation was 11 of 20 URD-BMT recipients and 23 of 30, respectively. One patient in the URD-BMT group died of a motor accident 5.5 years after BMT. Ten-year OS was 100% in MSD-BMT recipients and 93.8% (95% CI, 81.9-100%) in URD-BMT recipients, respectively (P = 0.252). Ten-year failure-free survival was 96.7% (95% CI, 90.2-100%) in the MSD-BMT group and 84.7% (95% CI, 70.2-99.2%) in the URD-BMT group, respectively (P = 0.161). Bone Marrow Transplantation (2010) 45, 1508-1513; doi:10.1038/bmt.2009.378; published online 1 February 2010