Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test.
Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test.
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DOI：
10.1176/ajp.142.11.1278
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
G. Gormley;Martin T. Lowy;Anthony T. Reder;V. Hospelhorn;J. Antel;Herbert Y. Meltzer
中科院分区：
文献类型：
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作者：
G. Gormley;Martin T. Lowy;Anthony T. Reder;V. Hospelhorn;J. Antel;Herbert Y. Meltzer
在标准化地塞米松抑制试验前后，对未用药的抑郁症患者和对照组淋巴细胞胞浆糖皮质激素受体含量进行定量。抑郁症患者（N = 11）的基础胞浆糖皮质激素受体含量显著低于（32%）对照组（N = 14）。在对照组和抑郁组（N = 16）中，地塞米松（1 mg）后血清皮质醇（5.0 μ g/dl或更低）的抑制与淋巴细胞胞浆糖皮质激素受体数量的减少有关，而皮质醇非抑制剂组（N = 9）则没有这种变化。受体浓度的变化与地塞米松后血清皮质醇水平和地塞米松对丝裂原诱导的淋巴细胞增殖的抑制作用呈正相关。
Cytoplasmic glucocorticoid receptor content wa quantitated in lymphocytes from unmedicated depressed patients and control subjects before and after a standardized dexamethasone suppression test. Depressed patients (N = 11) had significantly lower (32%) basal cytoplasmic glucocorticoid receptor content than the control group (N = 14). Suppression of serum cortisol (5.0 micrograms/dl or less) in both control and depressed subjects (N = 16) following dexamethasone (1 mg) was associated with a decrease in lymphocyte cytoplasmic glucocorticoid receptor number, whereas no such change occurred in cortisol nonsuppressors (N = 9). Changes in receptor concentration were positively correlated with postdexamethasone serum cortisol levels and with the inhibitory effect of dexamethasone on mitogen-induced lymphocyte proliferation.