PROTECTIVE EFFECTS OF HN AND F GLYCOPROTEIN-SPECIFIC MONOCLONAL-ANTIBODIES ON EXPERIMENTAL NEWCASTLE-DISEASE
PROTECTIVE EFFECTS OF HN AND F GLYCOPROTEIN-SPECIFIC MONOCLONAL-ANTIBODIES ON EXPERIMENTAL NEWCASTLE-DISEASE
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DOI：
10.1080/03079458608436338
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发表时间：
1986-01-01
期刊：
影响因子：
2.8
通讯作者：
LONG, L
中科院分区：
文献类型：
--
作者：
MEULEMANS, G;GONZE, M;LONG, L
抗NDV意大利株HN蛋白两个不同表位的单克隆抗体在体外和体内均能中和该病毒。5株抗NDV F蛋白的单克隆抗体对NDV Italien的中和活性各不相同，部分抗F单克隆抗体对NDV Italien的被动保护作用高于两株HN单克隆抗体的联合保护作用，甚至与兔多克隆抗血清的保护作用相当或更好。证明了F蛋白在抗NDV免疫应答中的重要性。
Monoclonal antibodies directed against two different epitopes of HN protein of NDV Italien neutralised this virus in bothin vitroandin vivotests. Moreover, the combination of these two HN monoclonal antibodies neutralised the Italien virus synergistically.Five monoclonal antibodies directed against the F protein of NDV had variable neutralising activity against NDV Italien.Passive protection afforded by some anti F monoclonal antibodies was higher than that observed with the combination of the two HN monoclonal antibodies and even equivalent or better than that obtained with rabbit polyclonal antiserum. The importance of the F protein in the immune response against NDV is demonstrated.