Development of the Northwestern Esophageal Quality of Life Scale: A Hybrid Measure for Use Across Esophageal Conditions.
Development of the Northwestern Esophageal Quality of Life Scale: A Hybrid Measure for Use Across Esophageal Conditions.
复制标题
西北食管生命质量量表的发展：一种在食管疾病中使用的混合量度。
DOI：
10.1038/ajg.2016.20
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Pandolfino J
中科院分区：
文献类型：
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作者：
Bedell A;Taft TH;Keefer L;Pandolfino J
慢性食道疾病如胃食道反流病、嗜酸性食管炎和贲门失弛缓症的健康相关生活质量(HRQOL)的测量被广泛用于衡量这一重要的患者报告的结果。我们寻求利用这些现有的措施来创建食道疾病的混合测量HRQOL(西北食道生活质量-NEQOL)，允许在各种疾病中广泛使用，同时保持对特定疾病细微差别的敏感性。遵循FDA患者报告结果(PRO)开发指南的三步混合方法流程：回顾现有的HRQOL测量项目并将其整合到单一问卷中；基于对具有代表性的食道疾病患者样本的回答进行信度和效度分析(主成分因素分析、Cronbachα、Guttman分半部分、项目间相关性、重测相关性和Pearson‘s与相关结构的相关性)；以及对患者进行个别结构化认知访谈，以进行项目细化和减少。创建了最初的30项措施。212名患者完成了研究的信度和效度部分，15名患者完成了认知访谈。因素分析和条目减少导致11个条目在患者访谈前从NEQOL中删除。结构效度与心理苦恼和一般的HRQOL有中等和显著的相关性。重测信度良好。在患者访谈后，由于地板效应或参与者反馈，另外5个条目被删除，产生了14个条目的HRQOL单量表测量。虽然还需要更多的研究，但NEQOL是一种可靠和有效的混合测量方法，可以衡量几种慢性食道疾病的特定疾病的HRQOL。
Measures of health-related quality of life (HRQOL) in chronic esophageal conditions such as gastroesophageal reflux disease, eosinophilic esophagitis, and achalasia are widely used to measure this important patient-reported outcome. We seek to leverage these existing measures to create a hybrid measure of esophageal illness HRQOL (the Northwestern Esophageal Quality of Life—NEQOL), allowing for broad use across diseases while maintaining sensitivity to nuances of a specific condition. A three-step, mixed-methods process per FDA guidelines for patient-reported outcome (PRO) development was followed: review and consolidation of existing HRQOL measure items into a single questionnaire, reliability and validity analyses (principle components factor analysis, Cronbach alpha, Guttman split-half, inter-item correlation, test–retest correlation, and Pearson’s correlation with related constructs) based on responses from a representative sample of esophageal illness patients, and individual structured cognitive interviews with patients for item refinement and reduction. An initial 30-item measure was created. Two-hundred twelve patients completed the reliability and validity portion of the study, and 15 completed cognitive interviews. Factor analysis and item-reduction resulted in 11 items being removed from the NEQOL prior to patient interviews. Construct validity was supported by moderate and significant correlations with psychological distress and general HRQOL. Test–retest reliability was excellent. Following patient interviews, an additional 5 items were removed because of floor effects or participant feedback yielding a 14-item, single scale measure of HRQOL. Although more research is warranted, the NEQOL is a reliable and a valid hybrid measure of disease-specific HRQOL across several chronic esophageal conditions.