Medial prefrontal cortex reacts to unfairness if this damages the self: a tDCS study
Medial prefrontal cortex reacts to unfairness if this damages the self: a tDCS study
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DOI：
10.1093/scan/nsu154
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发表时间：
2015-08-01
影响因子：
4.2
通讯作者：
Rumiati, Raffaella I.
中科院分区：
文献类型：
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作者：
Civai, Claudia;Miniussi, Carlo;Rumiati, Raffaella I.
不公平知觉的神经关联取决于谁是不公平待遇的目标。这些先前的发现表明，只有当测量的对象也是受不公平待遇影响的人时，内侧前额叶皮质(MPFC)的激活才与不公平感知有关。我们的目的是通过经颅直流电刺激(Tdcs)来证明MPFC受累的特异性，tdcs是一种在目标区域诱导皮质兴奋性变化的技术。我们使用最后通牒游戏的修改版本，在该游戏中，响应者既为自己(我-MS条件)也代表未知的第三方(TP条件)，其中他们对不公平做出反应而不是不公平的目标。我们发现，在多发性硬化症患者中，阴极型TDC的应用降低了拒绝不公平条件的概率，但在TP中没有；相反，同样的刺激增加了多发性硬化症患者拒绝公平条件的概率，但在多发性硬化症患者中没有。我们证实了MPFC与处理涉及自我的不公平有关的假说，并讨论了在多发性硬化症中刺激的相反效果的可能解释。
Neural correlates of unfairness perception depend on who is the target of the unfair treatment. These previous findings suggest that the activation of medial prefrontal cortex (MPFC) is related to unfairness perception only when the subject of the measurement is also the person affected by the unfair treatment. We aim at demonstrating the specificity of MPFC involvement using transcranial direct current stimulation (tDCS), a technique that induces cortical excitability changes in the targeted region. We use a modified version of the Ultimatum Game, in which responders play both for themselves (myself-MS condition) and on behalf of an unknown third-party (TP condition), where they respond to unfairness without being the target of it. We find that the application of cathodal tDCS over MPFC decreases the probability of rejecting unfair offers in MS, but not in TP; conversely, the same stimulation increases the probability of rejecting fair offers in TP, but not in MS. We confirm the hypothesis that MPFC is specifically related to processing unfairness when the self is involved, and discuss possible explanations for the opposite effect of the stimulation in TP.