Epidemiology and cardiovascular comorbidities in patients with psoriasis: A Korean nationwide population-based cohort study
Epidemiology and cardiovascular comorbidities in patients with psoriasis: A Korean nationwide population-based cohort study
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DOI：
10.1111/1346-8138.13761
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发表时间：
2017-06-01
影响因子：
3.1
通讯作者：
Kim, Jeong Eun
中科院分区：
文献类型：
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作者：
Oh, Eui Hyun;Ro, Young Suck;Kim, Jeong Eun
在亚洲人群中，缺乏对寻常型牛皮癣(PSV)和牛皮癣关节炎(PSA)的流行病学和共病的全国性研究。本研究的目的是确定韩国银屑病的人口学特征以及脑血管(CV)合并症的发生率，并比较患有PSA和PSV的人群之间的风险。这项队列研究从2002年到2010年在韩国国家健康保险数据库中的855 003名受试者中确定了15 484名银屑病患者。病例进一步分为PSA和PSV。我们使用来自单变量和年龄-性别调整的Logistic回归模型的危险比(HR)和95%可信区间(CI)来评估PSA和PSV患者合并疾病的风险。从2002年到2010年，牛皮癣的年患病率从313.2上升到453.5/10万人；然而，牛皮癣的总发病率略有下降(252.7-212.6/10万人口)。在银屑病患者中，10.8%患有PSA，在调整了年龄和性别后，PSA患者患血脂异常的风险显著高于PSV患者(调整后的HR，1.185；95%CI，1.049-1.338)。当按年龄组分层时，20-39岁的受试者患中风的风险更高，并且有许多心血管危险因素。总而言之，牛皮癣的患病率虽然在以前的报告范围内，但随着时间的推移，往往会增加。与PSV患者相比，PSA患者的特殊合并症负担更高，尤其是在相对较小的年龄阶段。
There is a lack of nationwide studies examining the epidemiology and comorbidities of psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) in Asian populations. The purpose of this study is to determine the demographics of psoriasis in Korea along with the incidence of cerebro-cardiovascular (CV) comorbidities and to compare these risks between populations with PsA and with PsV. This cohort study identified 15 484 patients with psoriasis among 855 003 subjects in the Korean National Health Insurance Database from 2002 through 2010. The cases were further classified into PsA and PsV. We used hazard ratios (HR) and 95% confidence intervals (CI) from the univariate and age-sex adjusted logistic regression model to assess the risk of comorbidities in patients with PsA and PsV. The annual prevalence of psoriasis increased from 313.2 to 453.5/100 000 people from 2002 through 2010; however, the overall incidence rate for psoriasis slightly decreased (252.7-212.6/100 000 population). Of psoriatic patients, 10.8% had PsA, and after adjusting for age and sex, PsA patients had a significantly higher risk of dyslipidemia than PsV patients (adjusted HR, 1.185; 95% CI, 1.049-1.338). When stratified by age group, subjects aged 20-39 years had a higher risk of stroke and many CV risk factors. In conclusion, the prevalence of psoriasis, while within the range of previous reports, tended to increase over time. Patients with PsA had higher burdens of specific comorbid diseases than those with PsV, especially at a comparatively early age.