GRANULOMATOUS HYPERSENSITIVITY TO TREHALOSE-6,6'-DIMYCOLATE (CORD FACTOR) IN MICE INFECTED WITH BCG
GRANULOMATOUS HYPERSENSITIVITY TO TREHALOSE-6,6'-DIMYCOLATE (CORD FACTOR) IN MICE INFECTED WITH BCG
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DOI：
10.1128/iai.7.4.631-638.1973
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发表时间：
1973-01-01
影响因子：
3.1
通讯作者：
YARKONI, E
中科院分区：
文献类型：
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作者：
BEKIERKUNST, A;YARKONI, E
乳液形式的脐带因子无法使小鼠对相同物质的后续攻击产生更广泛的肉芽肿反应。感染卡介苗的小鼠对脊髓因子敏感。这些动物对给予脐带因子的反应具有非常广泛的肉芽肿反应，比正常的反应强烈得多。这种超敏反应似乎是特异性的，与 PPD 迟发性超敏反应不同。对 BCG 杆菌致敏的小鼠施用 PPD 对肉芽肿反应没有影响。讨论了我们的发现及其重要性。
Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a subsequent challenge with the same substance. Mice infected with BCG bacilli are sensitized to cord factor. Such animals react to administration of cord factor with a very extensive granulomatous response, much stronger than normal ones. This hypersensitivity seems to be specific and is distinct from delayed hypersensitivity to PPD. PPD, administered to mice sensitized with BCG bacilli, has no effect on the granulomatous response. Our findings and their importance are discussed.